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Exclusive Handbook :
Large Fragment Knock-In (LFKI)
Mouse Models Using Recombinase-Mediated
Cassette Exchange (RMCE) Knock-in (KI) up to 300 kb | Conditional Knockout (cKO) up to 100 kb

Since the beginnings of gene editing research, the ability to accurately modify large genomic regions has remained a primary driver of innovation in the field. Although gene editing technologies have been continuously refined, the size of the modifiable region is still constrained depending on the methods used.

In this Exclusive Handbook, explore how to overcome limitations in large fragment knock-in (LFKI) research model development using recombinase-mediated cassette exchange (RMCE).

Fill out the form to receive your copy of this Exclusive Handbook, and learn how to develop LFKI mouse models for your research. >>

Outline of Contents
Site-Specific Recombination & Related Genome Modification Strategies
● Examples of SSR-based Strategies
Applications of Recombinase-Mediated Cassette Exchange (RMCE)
● LFKI Models – Humanization, Transgenic, Reporter, Conditional
● Developing Mutant Models for Comparative Analysis

Large Fragment Knock-in Mouse Models

About Cyagen

In under 15 years since its founding, Cyagen has become a leading provider of custom mouse and rat models – delivering over 78,470 models to researchers worldwide and receiving over 4,750 peer-reviewed citations. Cyagen provides researchers from around the world with transgenic, knockout, knockin, conditional knockout models and also offers a comprehensive series of stem cell products for research use, including cell lines, media, and differentiation kits.

Cyagen’s gene editing services are unparalleled in delivering research-ready rodent models with a guaranteed genotype. We even offer price matching to help ensure researchers get the best deal for their study. From strategy design through to delivery of research-ready custom mouse models, Cyagen offers complete outsourcing for all your animal model needs.

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