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Animal behavioral tests are important tools used in neuroscience research to evaluate behavioral phenotypes and establish rodent models of neuropsychiatric indications. Researchers are able to explore complex phenomena of life through a variety of behavioral assessments, including: the comprehensive evaluation of animal models' learning and memory, psychology, motor coordination, social behavior, and other phenotypic aspects of neurological disorders.

Rats and mice are the most commonly used animal models in neurobehavioral research due to their high degree of genetic homology with humans and wide variety of established disease models. After years of preparation, Cyagen's senior expert team has developed a rat and mouse neurobehavioral assessment platform. Cyagen offers rat and mouse behavioral assessment services using professional recording and analysis systems, including: water maze, novel object recognition test (NORT), Y maze, rotarod, open field test (OFT), forced swimming test (FST), elevated plus maze (EPM), and other types of rodent behavioral assessments. You can choose to use our behavioral platform to accelerate the phenotype evaluation process and conduct experiments on your own, or you can entrust Cyagen to provide one-stop services for your research model project. Our comprehensive services cover the entire process of model generation, from transgenic/gene targeting strategy design, model development, breeding, behavioral testing, phenotype assessments, evaluating surgery/drug treatment, and pathological marker detection; we have cultivated these capabilities to help you complete your research goals in a shorter time. Request a free consultation by contacting us at 800-921-8930, or email animal-service@cyagen.com.

Comprehensive Neurobehavioral Solutions for Rat and Mouse Models
Neurobehavioral Assessment Solutions for Testing Rats and Mice
Cyagen's platform for neuroscience studies offers a range of experimental setups for both rats and mice. Combined with our expertise in specialized model development and validation, we can facilitate your research projects on many aspects. Our comprehensive one-stop solution provides services spanning from model development, breeding, and drug administration to behavioral testing and other phenotype assessments. With our rich resources of both means and minds, Cyagen is equipped to deliver high-quality readouts for your neuroscience studies within a reasonable time.
Cyagen’s rat and mouse neurobehavioral platform has spaces available for rodent behavioral assessments, behavioral testing equipment, and professional recording and analysis systems, which can provide water maze, NORT, Y maze, rotarod, OFT, FST, EPM and other types of rat and mouse behavioral testing services. You can entrust Cyagen’s biotechnologists to conduct behavioral experiments, or you can choose to get our support for model development and conduct behavioral experiments on your own, talking to our custom animal model experts face to face as part of our high-quality technical support.
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Cyagen Platform for Neuroscience Studies
Applications
Applications
Alzheimer's diseaseAD
Parkinson's diseasePD
Amyotrophic lateral sclerosisALS
Duchenne muscular dystrophyDMD
Huntington’s diseaseHD
Rett syndromeRTT
Major depressive disorderMDD
Generalized anxiety disordersGAD
SchizophreniaSZ
Chronic PainCPS
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Learning and Memory
Motor Function
and Balance
Mental Disorders
Social Behavior
Pain
Morris Water Maze
Novel Object Recognition Test
Y-Maze
Applicable Fields
The water maze is widely used in research related to learning and memory, Alzheimer's, hippocampal studies, intelligence and aging, cognitive drug development/screening/evaluation, pharmacology, toxicology, preventive medicine and other neurological diseases and neuroscience-related research fields. It is the most recognized classic experiment in the study of learning and memory.
Applicable Fields
NORT is widely used in the study of cognitive dysfunction and its protective measures. Disorders such as Huntington's disease, Alzheimer's disease, and Schizophrenia have certain cognitive impairments during the onset and development. NORT is used to evaluate learning and memory phenotypes to establish animal models, and also conduct clinical research on the cause of disorders, prevention and treatment measures, and drug efficacy evaluations (pharmacodynamic analysis).
Applicable Fields
The Y-maze test includes a spontaneous alternation test and a recognition memory test. These tests have been shown to be sensitive to hippocampal damage, genetic manipulation, and amnesic drugs. It is mainly used in the test of discriminative learning, working memory and reference memory in animals.
Rotarod
Open Field Test
Balance Beam
Grip Strength
Gait analysis
Treadmill
Applicable Fields
The rotarod instrument can be used for fatigue experiments, skeletal muscle relaxation experiments, central nervous system inhibition experiments and other experiments that require exercise to detect the effect of drugs on exercise ability, such as:toxicity,substance deficiencies, specific cardiovascular and cerebrovascular drugs’ impact on motor function, etc.. The basic principles and basic functions of the instrument can be developed and utilized in numerous applications.
Applicable Fields
The OFT is used to observe and study the neuropsychological changes and various behaviors after entering the open environment of animals. One experiment can quantitatively evaluate the spontaneous activity, exploratory behavior, anxiety and depression state of animals, which has been widely used in the research and development of drugs.
Applicable Fields
The BB is a simple and straightforward test of balance and motor coordination. The researchers used the balance beam device to test the effects of stroke, Parkinson's disease, Huntington's disease, and traumatic brain injury on motor function. Diseases that reduce exercise capacity or damage the cerebral cortex cause a decline in subject performance on the BB test.
Applicable Fields
The grip strength test can evaluate the effects of drugs, muscle relaxants, diseases, aging, and nerve damage on muscle strength. It may also be used to evaluate the degree of aging, nerve injury, bone injury, muscle injury, ligament injury and degree of recovery in subjects.
Applicable Fields
Gait analysis is pivotal for studying neurodegenerative diseases like Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS). It helps evaluate the severity of motor deficits and the efficacy of therapeutic interventions. It is also used to study conditions like Duchenne muscular dystrophy (DMD), arthritis, or bone-related disorders, where gait changes reflect musculoskeletal abnormalities.
Applicable Fields
Treadmill testing is used across diverse research domains, including studies on neurological disorders, cardiovascular health, musculoskeletal function, metabolic diseases, and aging. It is also valuable in evaluating the effects of genetic modifications, drug efficacy, and rehabilitation strategies, as well as understanding exercise physiology and stress-related behaviors in rodent models.
Open Field Test
Forced Swimming Test
Elevated Plus Maze
Tail Suspension Test
Light/Dark box
Applicable Fields
OFT is used to observe and study the neuropsychological changes and various behaviors of animals after entering an open environment. One experiment can quantitatively evaluate the spontaneous activity, exploratory behavior, anxiety, and depression state of animals, which has been widely used in the research and development of drugs.
Applicable Fields
FST plays a crucial role in the research and development of antidepressants and their evaluation in animal models of depression. The FST is fast and simple, it is a highly reliable method which is widely used in the screening and evaluation of antidepressants.
Applicable Fields
The EPM is a classic behavioral test for disease research and is widely used in the development of new drugs, as well as in computer-assisted pharmacology, toxicology, preventive medicine, neurobiology, animal psychology, etc. It is an important tool for medical schools and research institutions to develop treatments for anxiety and depression.
Applicable Fields
The TST is a classic and rapid method for evaluating the efficacy of antidepressants, stimulants, and sedatives.
Applicable Fields
The light-dark box test is commonly employed in preclinical research to assess the effects of genetic modifications, pharmacological agents (e.g., anxiolytics or antidepressants), and environmental factors on anxiety-like behaviors. It is also used in stress and neuropsychiatric disorder models, providing valuable insights into the behavioral phenotypes of experimental rodent models.
Three-Chamber Social Interaction Test
Applicable Fields
The Three-Chamber social behavior experiment for mice is used as a behavioral evaluation platform for autism. The software calculates the time when the tested mice are close to a wire cage, the number of contacts and other indicators to evaluate the social behavior of the animals.
Electronic Von Frey
Hargreaves Test
Applicable Fields
The Electronic Von Frey test is primarily used in pain research, including studies of neuropathic pain, inflammatory pain, and hyperalgesia. It is also valuable for assessing sensory deficits or hypersensitivity in models of diabetes, spinal cord injury, arthritis, and neurodegenerative diseases. Additionally, this test is commonly used to evaluate the efficacy of analgesic drugs and other therapeutic interventions aimed at alleviating pain or restoring normal sensory function.
Applicable Fields
The Hargreaves test is extensively used in pain research, particularly for studying thermal hyperalgesia and allodynia in models of neuropathic pain, inflammation, and injury. It is also employed to evaluate the efficacy of analgesic drugs and to understand the molecular mechanisms underlying pain processing. Additionally, the test is applied in research on genetic modifications and neurodegenerative diseases that affect sensory and nociceptive pathways.
Service Advantages of Rat and Mouse
Neurobehavioral Platform

Multifunctional Animal Behaviour Platform

Cyagen’s rat and mouse neurobehavioral platform is equipped with exclusive water maze, Y maze, rotarod, open field, elevated plus maze and other types of experimental instruments and equipment, which can carry out tests of learning and memory, motor function/balance, psychological and social behaviors of rodent models.

Convenient Behavior Observation Record Analysis System

Cyagen's rat and mouse neurobehavioral platform is equipped with convenient behavioral observation and recording analysis software. Our software uses powerful animal identification and tracking capabilities in order to comprehensively and accurately reflect the behavioral status of rats and mice, which can help you save valuable research time, even enabling you to analyze multiple data streams simultaneously.

Comprehensive Guidance from a Team of Senior Technical Experts

Cyagen's rat and mouse neurobehavioral platform has a team of senior technical experts and experienced behavioral technical personnel in the fields of model construction and breeding, surgery/drug treatment, behavioral experiments, etc., — providing a full range of service guidance.

Interactive Experiment Space

Cyagen’s Gu'an Model Animal Center provides comprehensive model animal protection for researchers and pharmaceutical companies. In the Cyagen Gu'an Model Animal Center, visiting researchers not only have sufficient space for animal experiments, but also have close communication with experienced animal model experts and obtain high-quality technical support.
Rodent Models of Neurological Disorders
Type Product Application
HUGO-GT™ Models B6-hMECP2 Rett syndrome
B6-hMAPT Alzheimer's disease
B6-hTARDBP Amyotrophic lateral sclerosis
Genetic Models AD-M1 Alzheimer's disease
FVB-hHTT Q150 KI Huntington's disease
DMD-Q995 Duchenne muscular dystrophy
Induced Models 6-OHDA Treated Rats Parkinson's disease
MPTP-treated Mice Parkinson's disease
Chronic unpredictable mild stress Model Major depressive disorder
For more models introductions, please refer to the page: https://www.cyagen.com/us/en/services/drug-animal-models/neurological-disease-models.html