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Custom Models
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- ● Diet-Induced Obesity (DIO) Mouse Model
- ● Type 1 Diabetes Mellitus (T1DM) Mouse Model
- ● Type 2 Diabetes Mellitus (T2DM) Mouse Model
- ● Diet-induced Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Mouse Model
- ● Chemically Induced Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Mouse Model
- ● Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Mouse Model (Gene-editing)
- ● Composite (Combined) Model - Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Model
- ● Composite Model - Atherosclerosis Mouse Model
- ● Atherosclerosis Mouse Model (Gene-editing)
- ● Acute Pancreatitis Mouse Model
- ● Chronic Pancreatitis Mouse Model
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Testimonials
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Citations
IMMUNITY 47:107 (2017) IF=22.845
You may also be interested in
Item Number：C001343
Background：BALB/c
Genotype: Homozygous
Mouse Status: Homozygous knockout mice are developmentally normal and fertile
Surface membrane immunoglobulin (SmIg) of B cell membrane is a receptor that specifically recognizes antigens of B cells, and it is also an important characteristic marker of B cells. Early immature B cells express immunoglobulin M (IgM), while mature B cells express both mIgM and mIgD. Ighm Ighd-DKO homozygous mice lack mature B cells and can be used as an animal model of B cell immunodeficiency.
The double-gene knockout
(DKO) mouse model has knocked out Ighm gene exon 1~6 and Ighd gene exon 1~5.
Immunology; Inflammation; Autoimmunity Research.
• Detection of B cells
Figure 1. Detection of B cells in peripheral blood and spleen of Ighm Ighd-DKO homozygous mice
The results showed that B cell depletion was detected in the peripheral blood and spleen of Ighm Ighd-DKO homozygous mice.
Cyagen can provide you with a variety of drug evaluation models along with phenotype analysis services – delivering reliable and expedient data reporting for your project.
Inquiries and Quote Requests
Request a quote now. Alternatively, you can always email animal-service@cyagen.com or call 800-921-8930 to inquire about our services or obtain a quote for your project.
About Cyagen
● 15+ years' experience in custom animal model generation
● 78,000+ animal models generated and delivered worldwide
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