Animal Model Construction Service

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Different from the principles of traditional drug therapy, gene therapy regulates the expression of specific genes in the human body. Common gene therapy strategies include the introduction of normal genes (gene supplementation therapy), repair of defective genes (gene-editing therapy), and gene replacement therapy. The research of gene therapy is dependent on animal models of gene modification, surgical model, drug induction, and carrier modeling. As an international and innovative CRO platform based on research model animals, Cyagen makes the establishment of gene-edited animal models more efficient through its self-developed TurboKnockoutⓇ technology and CRISPR-Pro technology. In addition, Cyagen can provide surgical disease models and gene therapy vector model construction services.

Genetically Modified Animal Model

Gene therapy is effective in the treatment of a variety of genetic diseases and chronic diseases. Cyagen can provide animal models for researching rare diseases, neurological diseases, ophthalmic diseases, and other customized animal models for gene therapy.

Service Category	Case	Genetic Modification Method
Rare disease model	Thrombocytosis, Temple-Baraitser Syndrome (TMBTS), Intellectual Developmental Disorder, X-Linked, Syndromic 34 (MRXS34), etc.	Overexpression, Interference, Gene-editing
Nervous system disease model	Autism, Paroxysmal Nonkinesigenic Dyskinesia (PNKD), Lissencephaly, etc.
Eye disease model	Congenital Myopia, Wet Macular Degeneration, Familial Exudative Vitreoretinopathy (FEVR), etc.
Metabolic disease model	Hypercholesterolemia, Atherosclerosis Susceptibility (ATHS), etc.
Gene therapy customized model	Various gene-regulated cells, rat and mouse models

Cyagen Knockout Catalog Models Case

Cyagen Knockout Catalog Models provides over 16k research-ready gene knockout mice and conditional knockout mice. The powerful database gives you a more convenient experience. Researchers can search for their genes of interest, review the research model validation data, and submit an inquiry online. For example, there are many genes related to Amyotrophic Lateral Sclerosis (ALS), so we have developed a series of genetically modified animal models for these important disease genes for the Knockout Catalog Models. Combined with Cyagen's customized rat/mouse model development and rat/mouse breeding services, this can help you complete the task of constructing gene therapy animal models in a shorter period of time.

Type of Disease	KO/ cKO Knockout Live Mouse
Amyotrophic Lateral Sclerosis (ALS)	SOD1	TREM2	UNC13A	CCNF
	C9ORF72	OPTN	PON2	ANXA11
	PON1	NEFH	NEK1	SETX
	VCP	PPARGC1A	GLT8D1	TRPM7
	VAPB	EPHA4	GLE1	PARK7
	UBQLN2	CCS	ERBB4	……

Surgical Models Case

At present, animal disease models are established through acquired modeling (such as surgical or drug induction) and then treated by AAV injection, which is used in the field of gene therapy research. Cyagen has a strong and efficient surgical disease model team, which can provide customers with a variety of surgical model services including but not limited to: mental diseases, cardiovascular diseases, and metabolic diseases. In addition, we are also actively developing new surgical disease models. We are proficient in a variety of modeling technologies, and can complete the tasks from AAV vector construction to in vivo injection according to the needs of gene therapy researchers, truly providing you with a one-stop service of high-quality experience.

Type	Name	Experimental animal	Modeling method
Mental diseases	Depression	Mouse	Carotid artery ligation
Mental diseases	Menopausal depression/Osteoporosis	Mouse	Ovariectomy (OVX)
Cardiovascular diseases	Aortic Sclerosis	Mouse	Abdominal aortic constriction
	Stroke	Mouse	（MCAO）
	Myocardial ischemia	Mouse	Coronary artery ligation
Metabolic diseases	Liver damage	Mouse	Hepatic ischemia-reperfusion (HIR)
Metabolic diseases	Renal ischemia reperfusion Injury	Mouse	Nephrectomy

Gene Therapy Vector Modeling:

Gene therapy vector modeling refers to local injection and systemic injection of viral vectors containing disease-causing genes to cause disease phenotypes in the whole body or part of the animal's tissues, which can be used to prepare for future treatment experiments. It is usually suitable for homozygous lethal disease models and used to model diseases in specific tissues or cells.

Inquiries and Quote Requests

Request a quote now. Alternatively, you can always email animal-service@cyagen.com or call 800-921-8930 to inquire about our services or obtain a quote for your project.

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