Knockout mouse models are essential for understanding gene function. Absence of gene activity can elucidate the biological roles of a gene and its potential participation in pathogenesis of human disease. Providing in vivo data on the mechanism of action (MOA) can improve the significance of your publications and even expedite results.

Data from in vitro experiments are not reliable enough on their own; in vivo data is required to validate the target for a successful drug development program. Knockout mouse models provide robust, translatable data to ensure that your drug development program proceeds with accurate target validation, ensuring greater chances of clinical success.

The primary cause of drug failures is attributed to non-specificity, which may cause dangerous off-target effects. Knockout mice provide an in vivo system to detect potential off-target effects of drug candidates by removing specific functional protein target from the system. This allows researchers to ensure drug specificity and reduce the likelihood of off-target toxicity.