Autoimmune Disease Models

Autoimmune diseases are caused by the immune system's response to the body's own components. Under normal circumstances, the immune system can recognize and defend against foreign pathogens. However, when this regulation is lost, it may mistakenly attack and destroy healthy tissues and organs. Using mouse models, researchers can deeply explore the pathogenesis of autoimmune diseases, study the functions of specific genes, cells, and molecular pathways, and reveal key factors that lead to immune dysregulation and tissue damage.

Comprehensive Autoimmune Disease Mouse Models for Drug Evaluation

Cyagen offers specialized mouse models for autoimmune disease research and drug evaluation. Our models accurately mimic human autoimmune diseases, providing a crucial tool for understanding disease mechanisms and evaluating new treatments in preclinical trials.

Types of Autoimmune Disease Mouse Models

Cyagen provides a comprehensive range of autoimmune disease mouse models, including Tlr2 KO, Tlr3 KO, Tlr4 KO, and Nod2 KO, to support fundamental research and drug development for autoimmune diseases. Our models include:

  • Rheumatoid arthritis (RA) mouse models: Designed to study the pathogenesis and test new therapeutics for RA.
  • Multiple sclerosis (MS) mouse models: Ideal for exploring the mechanisms of MS and evaluating potential treatments.
  • Systemic lupus erythematosus (SLE) mouse models: Used to investigate SLE and develop novel drugs.
  • Type 1 diabetes (T1D) mouse models: Crucial for understanding T1D and testing interventions.
  • IgA nephropathy (IgAN) 

Autoimmune Disease Mouse Models Details:

Product Number Product Strain Background Application
C001535 BALB/c-Zap70*W163C (SKG) BALB/cAnCya Rheumatoid Arthritis (RA), Ankylosing Spondylitis (AS), Psoriasis-like Skin Inflammation, RA-associated Interstitial Lung Disease (RA-ILD), Crohn's Disease-like Ileitis, and other autoimmune diseases, as well as T-cell signaling research.
C001527 BALB/C-Il10 KO BALB/cAnCya Crohn's Disease and Other Inflammatory Bowel Diseases
C001230 Il10 KO C57BL/6NCya Inflammatory Bowel Disease (IBD); Cancer; Innate and Adaptive Immune Diseases
C001510 B6-hIL-17A C57BL/6NCya Psoriasis
C001268 Ifnar1 KO C57BL/6NCya Immune System Diseases
C001263 Tlr2 KO C57BL/6JCya Host Response to Bacterial Endotoxins (e.g., Septic Shock)
C001233 Tlr3 KO C57BL/6NCya Immune System Diseases
C001234 Tlr4 KO C57BL/6NCya Immune System Diseases
C001264 Nod2 KO C57BL/6NCya Crohn's Disease (CD), Other Inflammatory Bowel Diseases, Parkinson's Disease, Myocardial Infarction, Antithrombosis, Myocardial Ischemia, and Tumors
I001195 DBA/1-hTNF DBA/1 Research on rheumatoid arthritis (RA); studies on the TNF-α signaling pathway; research on the pathogenesis and treatment of other TNF-α-related diseases.


Regarding autoimmune-related diseases, we also offer various drug-induced autoimmune models, including Collagen-Induced Arthritis (CIA), Pulmonary Fibrosis, Systemic Scleroderma, Inflammatory Bowel Disease (DSS-induced IBD), Atopic Dermatitis (AD), Asthma, Induced SLE-like Model (Systemic Lupus Erythematosus), and Multiple Sclerosis (MS-EAE) models.

Drug-Induced Methods Disease
MOG35-55 Induced EAE Model in C57BL/6 Mice Autoimmune Encephalomyelitis
Pristane Induced SLE Model in BALB/c Mice Systemic Lupus Erythematosus
Bleomycin Induced SSc Model in BALB/c Mice Systemic Scleroderma
Bleomycin Induced Pulmonary Fibrosis Model in BALB/c Mice Pulmonary Fibrosis
DSS Induced IBD Model in C57BL/6 Mice Inflammatory Bowel Disease
Collagen Induced CIA Model in DBA/1 Mice Rheumatoid Arthritis
LPS Induced Acute Inflammation Model in Mice Acute Inflammation
IMQ Induced Psoriasis Model on the Back/Ears of BALB/c Mice Psoriasis
OVA Induced Atopic Dermatitis Model on the Back of BALB/c Mice Atopic Dermatitis
AchR-α97-116 Peptide Induced Myasthenia Gravis Model in C57BL/6 Mice Experimental Myasthenia Gravis

Benefits of Our Autoimmune Disease Mouse Models

Cyagen's autoimmune disease mouse models provide numerous benefits for researchers:

  • High genetic similarity to humans: Ensures accurate disease representation and reliable preclinical testing.
  • Reproducible results: Enables consistent and reliable data for your studies.
  • Cost-effective solutions: Our models offer a cost-efficient way to advance your autoimmune disease research.

Research and Development Support for Autoimmune Disease Models

At Cyagen, we provide extensive research and development support for your autoimmune disease projects. Our services include:

  • Model customization: Tailor-made mouse models to meet your specific research needs.
  • Data analysis services: Expert data analysis to help you interpret your research findings accurately.
  • Consultation and technical support: Ongoing guidance from our team of experts to ensure your project's success.

Contact Cyagen today to discover how our specialized autoimmune disease mouse models can accelerate your research and drug development.