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Catalog Number: I001152
Strain Name: C57BL/6JCya-Cspg4em1(P2A-CreERT2)/Cya
Genetic Background: C57BL/6JCya
Examples of Expressing Tissues/Cells: glial cells and vascular pericytes
Strain Description
The "Kozak-CreERT2-P2A" cassette was inserted upstream of the ATG start codon. CreERT2 recombinase is expressed under the regulatory control of Cspg4 gene elements. This model is a Tamoxifen-inducible Cre mouse, and when crossed with mice containing loxP sites, the offspring mice are expected to undergo sequence recombination between loxP sites mediated by Cre recombinase in Cspg4-positive cells (such as vascular pericytes and glial cells) following Tamoxifen induction.
Announcement
The insertion site of the CreERT2 recombinase gene expression cassette in this strain is located on chromosome 9. Please avoid breeding with gene-edited mice targeting genes on the same chromosome as the Cre mouse when conducting mating.