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- ● Diet-Induced Obesity (DIO) Mouse Model
- ● Type 1 Diabetes Mellitus (T1DM) Mouse Model
- ● Type 2 Diabetes Mellitus (T2DM) Mouse Model
- ● Diet-induced Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Mouse Model
- ● Chemically Induced Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Mouse Model
- ● Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Mouse Model (Gene-editing)
- ● Composite (Combined) Model - Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Model
- ● Composite Model - Atherosclerosis Mouse Model
- ● Atherosclerosis Mouse Model (Gene-editing)
- ● Acute Pancreatitis Mouse Model
- ● Chronic Pancreatitis Mouse Model
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Pcp2-P2A-CreERT2-T2A-mtdTomato Mice
Catalog Number: C001669
Strain Name: C57BL/6JCya-Pcp2em2(P2A-CreERT2-T2A-mtdTomato)/Cya
Genetic Background: C57BL/6JCya
Examples of Expressing Tissues/Cells: Purkinje cells of the cerebellum and Pcp2-positive cells
Strain Description
The TGA stop codon was replaced with "P2A-CreERT2-T2A-Membrane-tdTomato" cassette. CreERT2 recombinase and membrane-localized tdTomato are expressed under the regulatory control of Pcp2 gene elements. This model is a Tamoxifen-inducible Cre mouse, and when crossed with mice containing loxP sites, the offspring mice are expected to undergo sequence recombination between loxP sites mediated by Cre recombinase in Purkinje cells following Tamoxifen induction. In addition to Cre recombinase-mediated gene recombination studies, this model can also be used for membrane-localized tdTomato fluorescent protein tracing studies.
Announcement
The insertion site of the CreERT2 recombinase gene expression cassette in this strain is located on chromosome 8. Please avoid breeding with gene-edited mice targeting genes on the same chromosome as the Cre mouse when conducting mating.
