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Citations
IMMUNITY 47:107 (2017) IF=22.845
Usp26 KO Mice
Product Number：C001266
Genetic Background： C57BL/6NCya
Reproduction：Homozygous female x WT male
Strain Description
Ubiquitin-Specific Protease 26 (USP26), which belongs to the ubiquitination-specific processing protease family, is a deubiquitinating enzyme with histidine (His) and cysteine (Cys) structural domains. the USP26 gene is specifically expressed in testicular tissue as well as in the blood-testis barrier, and in premeiotic spermatogonia during spermatogenesis The gene is expressed in the spermatogonia before meiosis during spermatogenesis, including primitive A-, Ap- and B-type spermatogonia. The main diseases associated with USP26 are male infertility, including weak teratozoospermia, non-obstructive azoospermia (NOA), Sertoli cell-only syndrome (SCOS), and Klinefelter syndrome (KS). Homozygous Usp26 KO mice are viable but homozygous males are sterile.
The Usp26 gene is located on mouse chromosome X, and Exon 9 of this gene was deleted.
This strain can be used in the study of male hypo fertility associated with defective spermatogenesis including Creutzfeldt-Jakob syndrome.
References
[1] Liu C, Liu H, Zhang H, Wang L, Li M, Cai F, Wang X, Wang L, Zhang R, Yang S, Liu W, Liang Y, Wang L, Song X, Su S, Gao H, Jiang J, Li J, Luo M, Gao F, Chen Q, Li W, Chen ZJ. Paternal USP26 mutations raise Klinefelter syndrome risk in the offspring of mice and humans. EMBO J. 2021 Jul 1;40(13):e106864.
