Usp26 KO Mice

Catalog Number: C001266

Strain Name: C57BL/6NCya-Usp26^em1/Cya

Genetic Background: C57BL/6NCya

Reproduction: Hemizygous male x Homozygous female

Strain Description

Ubiquitin-Specific Protease 26 (USP26), which belongs to the ubiquitination-specific processing protease family, is a deubiquitinating enzyme with histidine (His) and cysteine (Cys) structural domains. the USP26 gene is specifically expressed in testicular tissue as well as in the blood-testis barrier, and premeiotic spermatogonia during spermatogenesis The gene is expressed in the spermatogonia before meiosis during spermatogenesis, including primitive A-, Ap- and B-type spermatogonia. The main diseases associated with USP26 are male infertility, including weak teratozoospermia, non-obstructive azoospermia (NOA), Sertoli cell-only syndrome (SCOS), and Klinefelter syndrome (KS). Homozygous Usp26 KO mice are viable.

Strain Strategy

The Usp26 gene is located on mouse chromosome X, and Exon 9 of this gene was deleted.

Application

This strain can be used in the study of male hypo fertility associated with defective spermatogenesis including Creutzfeldt-Jakob syndrome.

Publication
[1]Liu C, Liu H, Zhang H, Wang L, Li M, Cai F, Wang X, Wang L, Zhang R, Yang S, Liu W, Liang Y, Wang L, Song X, Su S, Gao H, Jiang J, Li J, Luo M, Gao F, Chen Q, Li W, Chen ZJ. Paternal USP26 mutations raise Klinefelter syndrome risk in the offspring of mice and humans. EMBO J. 2021 Jul 1;40(13):e106864.