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Citations
IMMUNITY 47:107 (2017) IF=22.845
You may also be interested in
H11-CAG-LSL-hMYC-IRES-EGFP Mice
Catalog Number: C001338
Strain Name: C57BL/6JCya-Igs2em1(CAG-LSL-HA tag-hMYC-IRES-eGFP)/Cya
Genetic Background: C57BL/6JCya
Strain Description
The MYC gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis, and cellular transformation. The MYC protein forms a heterodimer with the related transcription factor MAX, this complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of the MYC gene is frequently observed in numerous human cancers, MYC protein regulates the expression of a variety of genes related to cell proliferation and metabolic processes, and the MYC gene is also the most common high-abundance oncogene in human cancers. Translocations involving the MYC gene are associated with Burkitt lymphoma and multiple myeloma in human patients. The H11 safe harbor locus is located on mouse chromosome 11 and is capable of integrating exogenous genes driven by a designated promoter for stable expression. This strain carries a CAG promoter-driven LSL-hMYC-IRES-EGFP conditional overexpression structure inserted at the H11 safe harbor locus and overexpresses the human MYC gene in specific tissues or cells after mating with tissue-specific Cre mice.
Strain Strategy
Insertion of the “CAG-LSL-hMYC-IRES-EGFP” gene expression element into the H11 safe harbor locus in the mouse genome.
Strain Application
The model can be mated with different tissue-specific Cre mice for the study of tumors in different tissues or organs.
Validation Data
Alb-Cre+/MYC+ mice
A spontaneous liver tumor model obtained by mating H11-CAG-LSL-hMYC-IRES-EGFP mice with Alb-Cre mice.
1. The survival curve of Alb-Cre+/MYC+ mice
Figure 1. The survival curve of Alb-Cre+/MYC+ mice. The median survival time of Alb-Cre+/MYC+ mice is about 6 weeks.
2. Liver tumorigenesis in Alb-Cre+/MYC+ mice
Figure 2. Liver tumorigenesis in Alb-Cre+/MYC+ mice and wild-type (WT) mice. Compared to wild-type mice, Alb-Cre+/MYC+ mice at 3 weeks of age began to develop small liver tumors, and at 10 weeks of age, the tumors were significantly more and larger, with significant lesions.
