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Research Trends
Accelerating CAR-T Cell Therapy Research
Oct 13, 2022
By using the body's own immune system to kill tumor cells, immune cell therapy is anticipated to be a breakthrough strategy to "cure" many types of cancer. Among them, chimeric antigen receptor T-cell immunotherapy (CAR-T) has achieved remarkable results in the treatment of various hematological malignancies. As of 2022, seven CAR-T cell therapy products have been launched globally, including three in China. Read More >
Research Trends
Research Progress of CAR-T Therapy in Solid Tumor Treatment
Sep 23, 2022
CAR-T cell therapy research has developed rapidly in recent years, largely based on the remarkable efficacy of CAR-T therapy in hematological malignancies, and scientists are moving quickly to apply this innovative immunotherapy to the treatment of solid tumors, including sarcomas, carcinomas, and lymphomas. Herein, we review the background of CAR-T cell therapy in solid tumor treatment, common research targets, CAR-T optimization strategy, and clinical research progress. Read More >
Research Trends
A Study on The Mechanism of Achromatopsia
Sep 15, 2022
Patients with achromatopsia (ACHM) have abnormal color discrimination on the three color vision axes corresponding to the three cone cells. The patient's three cones, which sense red, green and blue, are completely inoperative, so they cannot distinguish between different colors. Read More >
Newsletter
Let's Meet at The 3rd Annual Gene Therapy for Ophthalmic Disorders in September!
Sep 05, 2022
The 3rd Annual Gene Therapy for Ophthalmic Disorders meeting is bringing you even more world class content, bringing you two tracks of learning to tackle the pressing challenges faced in the pre-clinical stages and in clinical development. This includes challenges faces with drug targets including wet AMD, dry AMD, DME, IRDs and more. Read More >
Research Trend
Mechanisms of Angelman Syndrome and Models for Research
Sep 01, 2022
Angelman syndrome (AS) is a rare brain disorder that affects about 1 in 20,000 newborns. Children with AS don't look much different from normal children on the surface—smiling and gentle. However, behind the angelic smile, there are a number of neurodevelopmental problems. The current treatment strategies for Angelman syndrome mainly focus on gene therapy, and the gene delivered by adeno-associated virus (AAV) vector treatment holds promise as a cure for the disease. Read More >
Research Trends
CRISPR-Pro-Mediated Gene Editing System for Effective Treatment of X-linked Retinitis Pigmentosa
Aug 09, 2022
Mutations in the retinitis pigmentosa GTPase regulator (RPGR) gene are associated with X-linked retinitis pigmentosa (XLRP), which accounts for 10% to 20% of all cases of retinitis pigmentosa (RP) and is one of its most severe forms. Herein, we review the research procedure that has culminated in the development of a potential gene therapy for XLRP caused by RPGR mutations. Read More >
Weekly Gene
The Culprits of Amyotrophic Lateral Sclerosis (ALS)
Aug 09, 2022
Age and heredity are currently recognized as the most relevant causative factors for amyotrophic lateral sclerosis (ALS), although age is also the biggest risk factor for many other neurodegenerative diseases. While inherited ALS accounts for only 5% of patients, there are more than 20 gene mutations identified as the pathological culprits of ALS. Read More >
Research Trends
Why CAR NK Cell Therapy Research Is Quickly Growing
Aug 05, 2022
What is CAR-T? The full name of CAR here is Chimeric Antigen Receptor, its structure includes extracellular domain, transmembrane domain, and an intracellular signal domain. Read More >
Research Trend
How to Measure the Viral Titer of Lentivirus Vectors?
Jun 06, 2022
In this article, we will introduce some commonly used lentivirus titer detection methods to assess the quality of the virus and maintain experimental consistency. Read More >
Research Trend
Lili Zhou's Team Reveals a New Mechanism of Renal Fibrosis
May 25, 2022
In March 2022, the team of Professor Lili Zhou from Southern Medical University in China published a paper entitled “β-catenin-controlled tubular cell-derived exosomes play a key role in fibroblast activation via the OPN-CD44 axis” in the Journal of Extracellular Vesicles, the top impact factor (IF=25.841) journal in the field of exosome research. Read More >