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Research Trends
Highly Efficient Human NK Cell Immune Reconstitution Mouse Models: NKG-hIL15 & huHSC-NKG-hIL15 Mice
Jul 12, 2024
Immunotherapy works by mobilizing immune cells within the body to enhance the immune system's ability to recognize, kill, and eliminate tumor cells. Given the differences between the immune systems of mice and humans, immunotherapies are typically evaluated in preclinical studies using humanized immune system (HIS) mouse models. Read More >
Research Trends
Hope for "Butterfly Children"—New Models in Research on Dystrophic Epidermolysis Bullosa (DEB)
Jul 05, 2024
In everyday life, hugging is a way for people to express love and kindness. However, for individuals with Epidermolysis Bullosa (EB), this simple act of intimacy can cause immense pain. Read More >
Research Trends
HFD+CCl4-Induced Metabolic Dysfunction-Associated Steatohepatitis (MASH/NASH) Mice
Jun 28, 2024
Metabolic dysfunction-associated steatohepatitis (MASH), previously referred to as nonalcoholic steatohepatitis (NASH), is a chronic liver disease. This condition frequently arises from metabolic irregularities like obesity or diabetes, leading to an accumulation of fat in the liver, which can become toxic and cause inflammation. Read More >
Research Trends
Recommended Model | Fabry Disease (FD) Research Model - Gla-KO Mice
Jun 21, 2024
Fabry Disease (FD) is a rare genetic disorder categorized as a lysosomal storage disease (LSD). It is caused by a deficiency in the activity of the lysosomal enzyme alpha-galactosidase A (α-GalA), leading to the accumulation of its metabolic substrate, Read More >
Research Trends
Beyond Obesity Research: B6-hGDF15 Humanized Mice for Tumor, Diabetes, Morning Sickness, and Cardiovascular Studies
Jun 17, 2024
Obesity is a major global health issue, and the discovery of new targets and the development of new therapies have always been focal points for researchers and pharmaceutical companies. Read More >
Research Trends
Inflammatory Bowel Disease Research Model—BALB/c-Il10 KO Mice for Studying Crohn's Disease & Ulcerative Colitis
Jun 11, 2024
The recent news that Kate Middleton, the Duchess of Cambridge, might be suffering from Crohn's Disease (CD) has drawn widespread public attention, leading more people to become aware of this condition, often referred to as "green cancer." Read More >
Research Trends
Next-Generation Humanized Models Construction Technology: TurboKnockout®
May 31, 2024
There are typically two techniques used for the genetic modification of mice: embryonic steam (ES) targeting and CRISPR. Read More >
The Value of hTTR & hTTR V50M Humanized Mice in Developing Therapies for Transthyretin Amyloidosis
May 24, 2024
A leading RNAi therapy company, Alnylam, recently disclosed its performance results for 2023, which revealed that its two siRNA drugs targeting transthyretin (TTR) for the treatment of amyloidosis, patisiran and vutrisiran, collectively generated sales exceeding $913 million. Read More >
Research Trends
Can B6-hIGHMBP2 Humanized Mice Offer a Breakthrough for Spinal and Peroneal Muscular Atrophy Research?
May 17, 2024
On January 23, 2024, Vanda Pharmaceuticals (VNDA) announced that its antisense nucleotide (ASO) drug VCA-894A targeting the IGHMBP2 gene has officially received FDA's Investigational New Drug (IND) approval. Read More >
Research Trends
Humanized Model for Therapeutic Targets of Parkinson's Disease Dementia: B6-hSNCA Mice
May 11, 2024
In this issue, we introduce the genetically humanized SNCA model - B6-hSNCA mouse (product number: C001427), providing a next-generation humanized mouse model for drug discovery for the key therapeutic target of Parkinson's Disease (PD) & Dementia with Lewy Bodies (DLB). Read More >