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Cyagen Knockout Catalog Model Resource - Improve Your Research Efficiency
May 06, 2021
With continuous advancement, our se Read More >
Newsletter
Research Trend
Cyagen Conditional Knockout Mouse Model Publication Alert
Apr 29, 2021
The following publications demonstrate the use of conditional knockout mouse models across a range of human disease research fields, including immunology, cardiology, metabolomics, oncology and more. Read More >
Research Trends
Case Study
Research Process of Alzheimer Disease
Apr 28, 2021
Alzheimer’s disease (AD) maintains the highest prevalence and morbidity among neurodegenerative diseases. Memory loss is the key symptom of AD, the aggravation of which will lead to other symptoms associated with the disease development, and eventually lead to death of the patients. AD brings suffering to the patients and their families - a heavy burden on society. Read More >
Research Trend
Conditional Knockout (cKO) Mice - Powerful Tool for Understanding Disease Mechanisms
Apr 26, 2021
Conditional knockout (cKO) mice can be used to study specific gene functions and related human diseases. Compared with traditional knockout (KO) mice, conditional knockout mice are obtained with a gene that deleted only in specific tissues or on an inducible basis. Compared with constitutively expressed gene mutations, conditional models provide greater temporal and regional control of gene expression – often serving as a more accurate model for studying human diseases. Read More >
Weekly Gene
LRRK2: A Pathogenic Gene of Parkinson's Disease (PD)
Apr 23, 2021
Parkinson's Disease (PD) is a neurodegenerative disease that cannot be cured. In this article, we review the background information, research insights and applications on LRRK2, a pathogenic gene of PD, providing useful information for further scientific innovation. Read More >
Weekly Gene
PRKN: A Pathogenic Gene of Parkinson's Disease (PD)
Apr 22, 2021
Parkinson's disease (PD) is a neurodegenerative disorder that affects behavior and motor skills. In this article, we review the background information, research insights, and applications related to PRKN, a pathogenic gene of PD. Read More >
Newsletter
Research Trend
Alzheimer's Disease Research Resources List
Apr 21, 2021
Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder, which affects 20 to 30 million individuals worldwide. Currently, no effective therapies to treat or cure this disease have been developed. Read More >
Research Trend
Transgenic Mice – Genetic Research Models Accelerating Drug Development
Apr 20, 2021
Transgenic mice are important tools for scientists to study genetic disorders and human diseases. In this article, we review the basic information on transgenic mice research, application examples, and the development process for transgenic mouse models – serving as a guide for scientists looking to gain proper understanding of transgenic mouse models. Read More >
Case Study
Research Trend
Intestinal Epithelial Cells Regulate the Differentiation of Intraepithelial Lymphocytes through the Expression of MHC II and PD-L1
Apr 20, 2021
The article entitled “Niche-specific MHC II and PD-LI regulate CD4+CD8aa+ intraepithelial lymphocyte differentiation,” published in the Journal of Experimental Medicine, first revealed the molecular mechanisms of intestinal epithelial cells (IECs) regulating T cell differentiation (IEL, intraepithelial lymphocytes). In addition, findings indicate the microbiome essential for the epithelial differentiation of MHCII, PD-L1, and IEL in the small intestine. Read More >
Weekly Gene
TARDBP: A Pathogenic Gene of Neurodegenerative Diseases
Apr 15, 2021
Neurodegenerative diseases have a multitude of factors contributing to their pathogenesis. In the first of our Weekly Gene features covering pathogenic genes of neurodegenerative diseases, we review the functionality of TARDBP. This review, as well as the upcoming Weekly Gene articles, aim to help researchers explore potential therapeutics for neurogenerative diseases. Read More >