Most Popular
|
Research Trend
|
| Conditional Knockout (cKO) Mice - Powerful Tool for Understanding Disease Mechanisms |
| Apr 26, 2021 |
| Conditional knockout (cKO) mice can be used to study specific gene functions and related human diseases. Compared with traditional knockout (KO) mice, conditional knockout mice are obtained with a gene that deleted only in specific tissues or on an inducible basis. Compared with constitutively expressed gene mutations, conditional models provide greater temporal and regional control of gene expression – often serving as a more accurate model for studying human diseases. Read More > |
|
Newsletter
Research Trend
|
| Alzheimer's Disease Research Resources List |
| Apr 21, 2021 |
| Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder, which affects 20 to 30 million individuals worldwide. Currently, no effective therapies to treat or cure this disease have been developed. Read More > |
|
Research Trend
|
| Transgenic Mice – Genetic Research Models Accelerating Drug Development |
| Apr 20, 2021 |
| Transgenic mice are important tools for scientists to study genetic disorders and human diseases. In this article, we review the basic information on transgenic mice research, application examples, and the development process for transgenic mouse models – serving as a guide for scientists looking to gain proper understanding of transgenic mouse models. Read More > |
|
Case Study
Research Trend
|
| Intestinal Epithelial Cells Regulate the Differentiation of Intraepithelial Lymphocytes through the Expression of MHC II and PD-L1 |
| Apr 20, 2021 |
| The article entitled “Niche-specific MHC II and PD-LI regulate CD4+CD8aa+ intraepithelial lymphocyte differentiation,” published in the Journal of Experimental Medicine, first revealed the molecular mechanisms of intestinal epithelial cells (IECs) regulating T cell differentiation (IEL, intraepithelial lymphocytes). In addition, findings indicate the microbiome essential for the epithelial differentiation of MHCII, PD-L1, and IEL in the small intestine. Read More > |
|
Research Trend
|
| Advancing Neurodegenerative Disease Research with Animal Models |
| Apr 08, 2021 |
| Population aging is one of the most important social health issues in the world today and will only increase in the future. With rising life expectancy and continually low fertility rate in developed economies, it is estimated that the number of people aged 65 years or over will be 2.1 billion by 2050 - reaching as many as 3.1 billion by 2100. Read More > |
|
Newsletter
Research Trend
|
| Knockout Mice - An Efficient Tool for Gene Function Research |
| Apr 02, 2021 |
| Knockout mice have been essential for gaining proper understanding of gene function, studying human disease mechanisms, and accelerating drug development - playing an important role in biomedical advancements across a variety of research areas. With the development of gene editing technology, knockout (KO) mice become increasingly accessible for researchers worldwide. In this article, we review the basic information on knockout mice research, application examples, and the development process for custom KO mouse models. Read More > |
|
Newsletter
Research Trend
|
| Rare Disease Research and Gene Therapy Resources List |
| Mar 29, 2021 |
| As a leading provider of custom mouse and rat models, Cyagen aims to support the advancement of rare disease and related gene therapy research with our expertise. We are committed to enabling development of therapeutics for rare diseases by developing accessible animal models to study disease mechanisms, target validation, drug screening and more. Read More > |
|
Case Study
Research Trend
|
| AAV-CRISPR-Pro-Mediated Gene Editing - An Efficient Tool for Atherosclerosis Research |
| Mar 18, 2021 |
| Familial hypercholesterolemia (FH) is characterized by elevated levels of low-density lipoprotein cholesterol (LDL-C) and premature cardiovascular disease (CVD). FH is an autosomal dominant genetic disease (with a gene dosage effect) that is caused by mutations in genes encoding low-density lipoprotein receptor (LDLR), apolipoprotein B (APOB) or subtilisin converting enzyme 9 (PCSK9). Around 90% of FH is caused by LDLR mutations. Read More > |
|
Research Trend
|
| Case Studies in Gene Therapy - Applications of Accurate Mouse Models |
| Mar 08, 2021 |
| Gene therapy introduces a modified gene into diseased cells to treat a genetic-based disease. The new gene usually contains a functioning gene to correct the effects of a disease-causing mutation, which may be either spontaneous or inherited. In the past few decades, gene therapy has made significant progress in the treatment of genetic diseases. In practice, scientists apply genomic and proteomic methods to identify the disease-causing gene, subsequently verifying the target gene with in vitro and in vivo experiments. With this methodology, scientists have published many high-impact gene therapy research articles. Read More > |
|
Research Trend
Newsletter
COVID-19
|
| Beyond Alzheimer’s Disease – Implications of APOE in Viral Pathology |
| Feb 09, 2021 |
| The APOE gene - which encodes Apolipoprotein E – has been extensively studied due to its biological relevance to a range of neurological and cardiovascular diseases, including Alzheimer’s Disease (AD). In addition to the roles APOE plays in developmental diseases such as AD, additional studies have shown APOE to be implicated in the host response to a range of infectious pathogens, including herpes simplex virus type I (HSV1) and hepatitis C virus (HCV). Read More > |
