Most Popular
Newsletter
Video
The PiggyBAC Transposon - Generating Transgenic Mice with Consistent Expression
Feb 23, 2021
In most experiments, scientists will try to minimize the number of independent variables so as not to confuse the results of an experiment. Due to the varying level of gene expression achieved by traditional pronuclear injection (PNI), using the offspring from a transgenic mouse created via PNI may not be the best option. Read More >
Research Trend
Newsletter
COVID-19
Beyond Alzheimer’s Disease – Implications of APOE in Viral Pathology
Feb 09, 2021
The APOE gene - which encodes Apolipoprotein E – has been extensively studied due to its biological relevance to a range of neurological and cardiovascular diseases, including Alzheimer’s Disease (AD). In addition to the roles APOE plays in developmental diseases such as AD, additional studies have shown APOE to be implicated in the host response to a range of infectious pathogens, including herpes simplex virus type I (HSV1) and hepatitis C virus (HCV). Read More >
Newsletter
Video
Pronuclear Injection-based Transgenic Mouse Model Generation
Feb 02, 2021
Transgenic mice are important tools for scientists researching heritable traits and diseases in human populations. In traditional transgenics, the human gene (packaged in a transgenic construct) can be added to the mouse genome with a simple pronuclear injection into the male pronucleus. Read More >
Newsletter
Research Trend
2020 In Review: Top 10 Custom Mouse Model Publications
Jan 22, 2021
As we review our accomplishments in 2020, we are delighted to share how our research partners have used our products and services to contribute to advances across numerous fields of study. Read More >
Newsletter
Video
How Knockout Mice are Developed with Traditional Gene Targeting
Jan 15, 2021
From the creation of the first knockout (KO) mouse, scientists have come extremely far. CRISPR technologies have quickly become a leading method used by genetic knockout scientists today, in part due to the method’s short turnaround. Read More >
Newsletter
Weekly Gene
[Gene of the Week] Alzheimer's Disease and Genes - APOE (Apolipoprotein E)
Dec 22, 2020
In our fourth Gene of the Week article, we continue covering genes related to the development of Alzheimer's disease (AD). Several mutations in APOE (Apolipoprotein E) have been identified to not only increase the risk of developing AD, but other neurological and cardiovascular diseases. Read More >
Newsletter
Announcing the Cyagen YouTube Channel
Dec 17, 2020
Have you ever searched on YouTube for a biology concept that you didn’t fully understand, only to come across basic whiteboard tutorials or grainy homemade videos with people who can’t clearly explain the concepts? Given Cyagen’s position as a leading provider of custom genetically modified mouse and rat models worldwide, we felt drawn to answer the call for quality explainer videos related to the field of gene engineering. Read More >
Newsletter
Weekly Gene
[Gene of the Week] Alzheimer's Disease and Genes - TREM2
Dec 14, 2020
Specific mutations in TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) have been confirmed to increase the risk of developing late-onset AD. Here, we review the current data detailing the function of TREM2 and its role in Alzheimer's disease (AD). Read More >
Newsletter
Large Fragment Knock-In Mouse Models Using Recombinase-Mediated Cassette Exchange
Dec 10, 2020
Since the beginnings of gene editing research, the ability to accurately modify large genomic regions has remained a primary driver of innovation in the field. Although gene editing technologies have been continuously refined, the size of the modifiable region is still constrained depending on the methods used. Read More >
Newsletter
New Cyagen Custom Mouse Model Publication Alert – December 2020
Dec 01, 2020
Herein, we have selected several high-impact factor (IF) publications from May through October 2020, which use custom genetically modified mouse models developed by Cyagen. These citations cover a broad range of research fields, including immunology, inflammation, cardiology, oncology, metabolomics, and epigenetics. Read More >