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Research Process of Alzheimer Disease
Apr 28, 2021
Alzheimer’s disease (AD) maintains the highest prevalence and morbidity among neurodegenerative diseases. Memory loss is the key symptom of AD, the aggravation of which will lead to other symptoms associated with the disease development, and eventually lead to death of the patients. AD brings suffering to the patients and their families - a heavy burden on society. Read More >
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Intestinal Epithelial Cells Regulate the Differentiation of Intraepithelial Lymphocytes through the Expression of MHC II and PD-L1
Apr 20, 2021
The article entitled “Niche-specific MHC II and PD-LI regulate CD4+CD8aa+ intraepithelial lymphocyte differentiation,” published in the Journal of Experimental Medicine, first revealed the molecular mechanisms of intestinal epithelial cells (IECs) regulating T cell differentiation (IEL, intraepithelial lymphocytes). In addition, findings indicate the microbiome essential for the epithelial differentiation of MHCII, PD-L1, and IEL in the small intestine. Read More >
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AAV-CRISPR-Pro-Mediated Gene Editing - An Efficient Tool for Atherosclerosis Research
Mar 18, 2021
Familial hypercholesterolemia (FH) is characterized by elevated levels of low-density lipoprotein cholesterol (LDL-C) and premature cardiovascular disease (CVD). FH is an autosomal dominant genetic disease (with a gene dosage effect) that is caused by mutations in genes encoding low-density lipoprotein receptor (LDLR), apolipoprotein B (APOB) or subtilisin converting enzyme 9 (PCSK9). Around 90% of FH is caused by LDLR mutations. Read More >