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Research Trend
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| Mechanisms of Angelman Syndrome and Models for Research |
| Sep 01, 2022 |
| Angelman syndrome (AS) is a rare brain disorder that affects about 1 in 20,000 newborns. Children with AS don't look much different from normal children on the surface—smiling and gentle. However, behind the angelic smile, there are a number of neurodevelopmental problems. The current treatment strategies for Angelman syndrome mainly focus on gene therapy, and the gene delivered by adeno-associated virus (AAV) vector treatment holds promise as a cure for the disease. Read More > |
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Research Trend
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| How to Measure the Viral Titer of Lentivirus Vectors? |
| Jun 06, 2022 |
| In this article, we will introduce some commonly used lentivirus titer detection methods to assess the quality of the virus and maintain experimental consistency. Read More > |
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Research Trend
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| Lili Zhou's Team Reveals a New Mechanism of Renal Fibrosis |
| May 25, 2022 |
| In March 2022, the team of Professor Lili Zhou from Southern Medical University in China published a paper entitled “β-catenin-controlled tubular cell-derived exosomes play a key role in fibroblast activation via the OPN-CD44 axis” in the Journal of Extracellular Vesicles, the top impact factor (IF=25.841) journal in the field of exosome research. Read More > |
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Research Trend
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| What is Huntington's Disease? |
| May 20, 2022 |
| Huntington's disease (HD), also known as Huntington's chorea, is a neurodegenerative disease that has a 50% probability of being inherited by children of people living with HD. Read More > |
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Research Trend
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| Amyotrophic Laternal Sclerosis (ALS) - A Rare Disease More Common in EU&US |
| May 16, 2022 |
| ALS is a motor neuron disease (MND), which is a group of neurological disorders that selectively affect motor neurons with secondary damage to muscles. The data shows that the incidence rate in Europe and the United States is higher, at 2.6/105, and the prevalence rate is almost double, at 7-9/105. Read More > |
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Research Trend
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| Racing Against Time to Treat Amyotrophic Lateral Sclerosis (ALS), A Fatal Disease |
| May 11, 2022 |
| Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a neurodegenerative disease that results in the progressive loss of motor neurons that control voluntary muscles. Read More > |
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Research Trend
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| Preclinical Pharmacological Model of CAR T-Cell Therapy |
| May 06, 2022 |
| Recently, the U.S. Food and Drug Administration (FDA) has approved Carvykti, a chimeric antigen receptor (CAR) T-cell therapy product jointly developed by Legend Biotech and Johnson & Johnson, for the treatment of relapsed/refractory multiple myeloma. Read More > |
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Research Trend
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| What Do You Know about the Quality Control of rAAV Virus? |
| May 02, 2022 |
| The production and preparation of rAAV is a key and difficult point in gene therapy, because the packaging system and purification method of rAAV will influence the infection efficiency and the expression efficiency of the target gene, and ultimately affect the results. Read More > |
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Research Trend
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| A Method to Study the Mechanisms of Gene Regulation |
| Apr 29, 2022 |
| In December 2021, Shengde Wu’s group from the Department of Urology, Children's Hospital of Chongqing Medical University, published in a paper at Journal of Hazardous Materials, entitled Di-(2-ethylhexyl) phthalate exposure leads to ferroptosis via the HIF-1α/HO-1 signaling pathway in mouse testes. Read More > |
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Research Trend
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| How AI + Minigene Aids the Research of Aberrant Alternative Splicing |
| Apr 26, 2022 |
| Alternative splicing is the regulatory process of selecting different combinations of splice sites within a messenger RNA precursor (pre-mRNA) to produce variably spliced mRNAs. These multiple mRNAs can encode proteins that vary in their sequence and activity and yet all arise from a single gene. Read More > |
