Most Popular
|
Weekly Gene
|
| Pathogenic Gene of Neurodevelopmental Disorders - MECP2 Gene |
| May 27, 2021 |
| Neurodevelopmental disorders are impairments of the brain and central nervous system that affect a patient’s behavior and cognition. In this article we review the MECP2 gene, a pathogenic gene of neurodevelopmental disorders, hoping to help researchers gaining proper understanding of the gene, its encoded MeCP2 protein, and related neurodevelopmental disorders. Read More > |
|
Newsletter
|
| Myriad of CRISPR Research Model Services |
| May 27, 2021 |
| If your lab is utilizing CRISPR in animal or in-vitro modeling work, we have a wide variety of CRISPR offerings with great discounts. Read More > |
|
Newsletter
|
| Announcement - Introducing Cyagen Upgraded Animal Supporting Services |
| May 27, 2021 |
| yagen aims to support biomedical research with our expertise. We are committed to enabling development of precise animal models to help researchers study disease mechanisms, target validation, drug screening and more. Our comprehensive services cover the entire process of animal model generation - from gene targeting strategy design and animal model development, through to breeding and animal phenotype analysis – to accelerate your scientific research progress. Read More > |
|
Newsletter
|
| What Are Transgenic Rats |
| May 27, 2021 |
| Transgenic rats are animal models which have foreign DNA incorporated into the rat genome and are used to research a wide range of gene functions and human diseases. Read More > |
|
Newsletter
|
| How to Effectively Generate CRISPR Gene Knockout Cell Lines? Choosing a Transfection Method |
| May 25, 2021 |
| After deciding upon a CRISPR-mediated gene knockout strategy and obtaining the gRNA, the next step would be choosing the suitable strategy for cell transfection to introduce gRNA and Cas9 protein into cells. The efficiency of this transfection step directly affects the overall success rate of CRISPR/Cas-mediated gene editing and subsequent model generation. Read More > |
|
Newsletter
|
| Advancing Research with Humanized Mouse Models |
| May 20, 2021 |
| A humanized mouse model is a broad term referring to a mouse engrafted with functional human genes, cells, or tissues. This type of model is usually used as an powerful in vivo model for preclinical study of human diseases. Humanized mouse models have become an important animal model for identifying how human genes impact development and disease. Read More > |
|
Newsletter
|
| What is a Knockin Mouse? |
| May 20, 2021 |
| Gene knock-in (KI), a.k.a. knockin, mice are generated by introducing specific mutations or exogenous genes into specific sites of the target gene through homologous recombination, so that the expression of the gene knockin may be tracked through the expression of a reporter. Read More > |
|
Newsletter
|
| Animal Models for Metabolic Disease Research |
| May 20, 2021 |
| Animal Models for Metabolic Disease Read More > |
|
Newsletter
|
| How to Choose the Best Knockout Cell Line Strategy |
| May 18, 2021 |
| The traditional approaches used in gene function studies, especially in cell lines, include gene interference, gene overexpression, and gene knockout. Herein, we will focus on discussing the most popular approach, gene knockout – a mutation that inactivates a gene function. Read More > |
|
Video
|
| Using CRISPR to Develop Knockout Mouse Models for Research |
| May 17, 2021 |
| Engineered nuclease-mediated genome editing, especially CRISPR, has emerged as a promising technology which can serve as an alternative to the conventional, embryonic stem (ES) cell homologous recombination-based generation of animal models. Read More > |
