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Weekly Gene
LRRK2: A Pathogenic Gene of Parkinson's Disease (PD)
Apr 23, 2021
Parkinson's Disease (PD) is a neurodegenerative disease that cannot be cured. In this article, we review the background information, research insights and applications on LRRK2, a pathogenic gene of PD, providing useful information for further scientific innovation. Read More >
Weekly Gene
PRKN: A Pathogenic Gene of Parkinson's Disease (PD)
Apr 22, 2021
Parkinson's disease (PD) is a neurodegenerative disorder that affects behavior and motor skills. In this article, we review the background information, research insights, and applications related to PRKN, a pathogenic gene of PD. Read More >
Newsletter
Research Trend
Alzheimer's Disease Research Resources List
Apr 21, 2021
Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder, which affects 20 to 30 million individuals worldwide. Currently, no effective therapies to treat or cure this disease have been developed. Read More >
Research Trend
Transgenic Mice – Genetic Research Models Accelerating Drug Development
Apr 20, 2021
Transgenic mice are important tools for scientists to study genetic disorders and human diseases. In this article, we review the basic information on transgenic mice research, application examples, and the development process for transgenic mouse models – serving as a guide for scientists looking to gain proper understanding of transgenic mouse models. Read More >
Case Study
Research Trend
Intestinal Epithelial Cells Regulate the Differentiation of Intraepithelial Lymphocytes through the Expression of MHC II and PD-L1
Apr 20, 2021
The article entitled “Niche-specific MHC II and PD-LI regulate CD4+CD8aa+ intraepithelial lymphocyte differentiation,” published in the Journal of Experimental Medicine, first revealed the molecular mechanisms of intestinal epithelial cells (IECs) regulating T cell differentiation (IEL, intraepithelial lymphocytes). In addition, findings indicate the microbiome essential for the epithelial differentiation of MHCII, PD-L1, and IEL in the small intestine. Read More >
Weekly Gene
TARDBP: A Pathogenic Gene of Neurodegenerative Diseases
Apr 15, 2021
Neurodegenerative diseases have a multitude of factors contributing to their pathogenesis. In the first of our Weekly Gene features covering pathogenic genes of neurodegenerative diseases, we review the functionality of TARDBP. This review, as well as the upcoming Weekly Gene articles, aim to help researchers explore potential therapeutics for neurogenerative diseases. Read More >
Weekly Gene
SNCA: A Pathogenic Gene of Neurodegenerative Diseases
Apr 15, 2021
It is well known that genes play a major role in the pathogenesis of neurodegenerative diseases. There have been major efforts in biomedical research to learn about disease-related genes, which has led to highly targeted therapeutics for several diseases that were previously untreatable. Read More >
Research Trend
Advancing Neurodegenerative Disease Research with Animal Models
Apr 08, 2021
Population aging is one of the most important social health issues in the world today and will only increase in the future. With rising life expectancy and continually low fertility rate in developed economies, it is estimated that the number of people aged 65 years or over will be 2.1 billion by 2050 - reaching as many as 3.1 billion by 2100. Read More >
Newsletter
Research Trend
Knockout Mice - An Efficient Tool for Gene Function Research
Apr 02, 2021
Knockout mice have been essential for gaining proper understanding of gene function, studying human disease mechanisms, and accelerating drug development - playing an important role in biomedical advancements across a variety of research areas. With the development of gene editing technology, knockout (KO) mice become increasingly accessible for researchers worldwide. In this article, we review the basic information on knockout mice research, application examples, and the development process for custom KO mouse models. Read More >
Newsletter
Research Trend
Rare Disease Research and Gene Therapy Resources List
Mar 29, 2021
As a leading provider of custom mouse and rat models, Cyagen aims to support the advancement of rare disease and related gene therapy research with our expertise. We are committed to enabling development of therapeutics for rare diseases by developing accessible animal models to study disease mechanisms, target validation, drug screening and more. Read More >