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Newsletter
How to Choose the Best Knockout Cell Line Strategy
May 18, 2021
The traditional approaches used in gene function studies, especially in cell lines, include gene interference, gene overexpression, and gene knockout. Herein, we will focus on discussing the most popular approach, gene knockout – a mutation that inactivates a gene function. Read More >
Video
Using CRISPR to Develop Knockout Mouse Models for Research
May 17, 2021
Engineered nuclease-mediated genome editing, especially CRISPR, has emerged as a promising technology which can serve as an alternative to the conventional, embryonic stem (ES) cell homologous recombination-based generation of animal models. Read More >
Newsletter
Breaking News
Taconic-Cyagen Custom Animal Model Awards (CAMA) Announces 6 Winners
May 14, 2021
We are delighted to announce the winners of the first Taconic-Cyagen Custom Animal Model Awards (CAMA) competition. Read More >
Newsletter
THE TACONIC-CYAGEN ACADEMIC MODEL GENERATION ALLIANCE
May 13, 2021
The Taconic-Cyagen Academic Model Generation Alliance (The Alliance) has capabilities to ensure the success of any project. The Alliance provides specially-tailored products and services for the academic and non-profit markets. Together, we have streamlined the model design process to provide the academic market access to premium model generation and colony management services backed by comprehensive capabilities and cutting-edge, fully licensed technologies with competitive pricing. As partners, Taconic and Cyagen leverage the power of our complementary approaches to provide customers with the best and most competitive solutions for their projects. Read More >
Latest Discovery
Research Trend
LARP7-Mediated U6 snRNA Modification and Its Role in Pre-mRNA Splicing As Well As Its Functions in Mouse Spermatogenesis
May 11, 2021
In higher eukaryotes, most genes co Read More >
Research Trend
Research Process of Parkinson’s Disease
May 10, 2021
PD ranks second among neurodegenerative diseases. The most well-known symptom of PD is involuntary tremors, characterized by uncontrolled shaking, most notably in the hands. Another important symptom is the weakening of balance ability, but it should be noted that the weakening of balance has nothing to do with cerebellar injury. Read More >
Newsletter
Cyagen Knockout Catalog Model Resource - Improve Your Research Efficiency
May 06, 2021
With continuous advancement, our se Read More >
Newsletter
Research Trend
Cyagen Conditional Knockout Mouse Model Publication Alert
Apr 29, 2021
The following publications demonstrate the use of conditional knockout mouse models across a range of human disease research fields, including immunology, cardiology, metabolomics, oncology and more. Read More >
Research Trends
Case Study
Research Process of Alzheimer Disease
Apr 28, 2021
Alzheimer’s disease (AD) maintains the highest prevalence and morbidity among neurodegenerative diseases. Memory loss is the key symptom of AD, the aggravation of which will lead to other symptoms associated with the disease development, and eventually lead to death of the patients. AD brings suffering to the patients and their families - a heavy burden on society. Read More >
Research Trend
Conditional Knockout (cKO) Mice - Powerful Tool for Understanding Disease Mechanisms
Apr 26, 2021
Conditional knockout (cKO) mice can be used to study specific gene functions and related human diseases. Compared with traditional knockout (KO) mice, conditional knockout mice are obtained with a gene that deleted only in specific tissues or on an inducible basis. Compared with constitutively expressed gene mutations, conditional models provide greater temporal and regional control of gene expression – often serving as a more accurate model for studying human diseases. Read More >