Weekly Gene
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Immunology and Inflammation Research - IL17A |
Mar 17, 2021 |
Since IL17A plays an important role in infectious diseases, inflammatory, autoimmune diseases and cancer studies, IL17A has become a hot research target for many studies. In this Gene of the Week article, we have collected some insights on IL17A research progress and development trends, aiming to inspire even more scientific innovations. Read More > |
Video
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Comparing Mouse and Rat Models for Research |
Mar 12, 2021 |
As researchers seek the most accurate animal models for in vivo experiments, the availability of gene-editing technologies for developing both mouse and rat models has created more options than ever before. Murine genomes share great similarity with the human genome, which has made them fantastic models for a wide range human disease research. Read More > |
Research Trend
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Case Studies in Gene Therapy - Applications of Accurate Mouse Models |
Mar 08, 2021 |
Gene therapy introduces a modified gene into diseased cells to treat a genetic-based disease. The new gene usually contains a functioning gene to correct the effects of a disease-causing mutation, which may be either spontaneous or inherited. In the past few decades, gene therapy has made significant progress in the treatment of genetic diseases. In practice, scientists apply genomic and proteomic methods to identify the disease-causing gene, subsequently verifying the target gene with in vitro and in vivo experiments. With this methodology, scientists have published many high-impact gene therapy research articles. Read More > |
Newsletter
Weekly Gene
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Pathogenic Genes of Rare Disease - SMN1 in Spinal Muscular Atrophy Research |
Mar 05, 2021 |
cord, which affects the central nervous system, peripheral nervous system, and voluntary muscle movement. The primary pathogenic gene of spinal muscular atrophy is the survival of motor neuron 1 (SMN1) gene, mutations of which cause a deficiency of SMN motor neuron protein – ultimately resulting in Chromosome 5 SMA, the most common form of SMA. Read More > |
Newsletter
Breaking News
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Rare Disease Day 2021 – Achieving Equity |
Feb 26, 2021 |
With over 300 million people worldwide living with a rare disease, Rare Disease Day aims to raise awareness of what it means to be rare. On the last day of February each year, the Rare Disease community comes together to work toward more equitable access to diagnosis, treatment, care, and social opportunity for people with a rare disease. Read More > |
Newsletter
Weekly Gene
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【Gene of the Week】Metabolism & Cardiovascular Diseases - SIRT3 |
Feb 26, 2021 |
The SIRT3 gene plays an important role in the pathogenesis of metabolic, cardiovascular, and neurodegenerative diseases. In this article, we review the functionality of SIRT3 and explore its role in metabolism & cardiovascular disease studies - bringing together insights to SIRT3 gene research developments to provide inspiration for your scientific innovation. Read More > |
Newsletter
Video
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The PiggyBAC Transposon - Generating Transgenic Mice with Consistent Expression |
Feb 23, 2021 |
In most experiments, scientists will try to minimize the number of independent variables so as not to confuse the results of an experiment. Due to the varying level of gene expression achieved by traditional pronuclear injection (PNI), using the offspring from a transgenic mouse created via PNI may not be the best option. Read More > |
Weekly Gene
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[Gene of the Week] The Next Generation Target for Immunotherapy - CD134 (TNFRSF4) |
Feb 18, 2021 |
Immune checkpoint proteins (ICP) are a group of signaling molecules possessed by immune cells that can regulate and control the persistence of immune response. The immune checkpoint signaling pathway consists of inhibitory and stimulatory pathways that maintain self-tolerance and assist with the immune response. Read More > |
Research Trend
Newsletter
COVID-19
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Beyond Alzheimer’s Disease – Implications of APOE in Viral Pathology |
Feb 09, 2021 |
The APOE gene - which encodes Apolipoprotein E – has been extensively studied due to its biological relevance to a range of neurological and cardiovascular diseases, including Alzheimer’s Disease (AD). In addition to the roles APOE plays in developmental diseases such as AD, additional studies have shown APOE to be implicated in the host response to a range of infectious pathogens, including herpes simplex virus type I (HSV1) and hepatitis C virus (HCV). Read More > |
One-Minute Survey: Cyagen Knockout Catalog Models Improve our offerings and receive $2,000 credit! |
Feb 04, 2021 |
Given your interest in and/or purchase from the Cyagen Knockout Catalog Models repository, we would appreciate your participation in a one-minute survey. Your feedback will be used to improve our catalog offerings. Read More > |