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Ten Deadly Sins of Rare Diseases
Application of Humanized Mouse Models in DNA Repeat Expansion Diseases [Ten Deadly Sins of Rare Diseases Ⅵ]
Nov 15, 2023
Enter the 'Ten Deadly Sins of Rare Diseases' column to unlock the mechanisms of rare disease occurrence and development, industry research advancements (such as gene therapy), and innovative strategies for advancing clinical outcomes (including model construction and drug screening). Read More >
Research Trends
What are rare immunological diseases? Exploring the Advantages of C-NKG Severe Immunodeficient Mice
Nov 03, 2023
Do you recall the famous "Bubble Boy"? Poor David suffered from Severe Combined Immunodeficiency (SCID), which made him incapable of combatting any bacteria or viruses, forcing him to spend his entire life in a sterile environment. Shortly after his birth, doctors placed him into a sterile bubble, hence the term "Bubble Boy" for people with similar conditions. Today, let's delve deeper into immunodeficiency disorders. Read More >
Research Trends
Congenital Genetic Abnormalities & Related Phenotypes in Rat Models of Human Diseases
Oct 27, 2023
In addition to factors related to routine husbandry practices, rats are also susceptible to various genetic diseases, known as congenital genetic abnormalities. Today, we will introduce some congenital genetic abnormalities commonly seen in rats. Read More >
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HistoWiz and Cyagen Collaborate to Streamline Histopathology for Academic and Preclinical Mouse and Rat Model Research
Oct 23, 2023
SALT LAKE CITY, Utah–AALAS 2023–Booth #2717– (October 23, 2023)--HistoWiz, a leading provider of histology and slide archiving services, and Cyagen Biosciences, an AI-enabled CRO company specializing in custom genetically engineered animal and cell models for research, announced today at the American Association for Laboratory Animal Science (AALAS) a strategic co-marketing partnership to streamline histopathology services. Read More >
Ten Deadly Sins of Rare Diseases
Is Smn2 Gene Therapy the Key to Treating Spinal Muscular Atrophy? [Ten Deadly Sins of Rare Diseases Ⅴ]
Oct 20, 2023
In support of August being annually recognized as International SMA Awareness Month, Part V of our "Ten Deadly Sins of Rare Diseases" article series will focus on Spinal Muscular Atrophy (SMA). Read More >
Research Trends
Maintaining Rat Colony Health: A Guide to Non-infectious Diseases in Rats
Oct 17, 2023
Disease prevention, daily care and experimental procedures for rats are vital for the well-being and health of rats. Today, we will introduce some non-infectious diseases that affect rats, across the categories of genetic predisposition to disease, nutritional disorders, colony management-related disorders, and iatrogenic (injury-related) illnesses. Read More >
Research Trends
Taking a Closer Look at Common Animal Models for Tumor Diseases: Colorectal Cancer
Sep 28, 2023
Colorectal cancer is a common malignancy that occurs in the colon, a part of the digestive tract. It is typically found at the junction of the rectum and sigmoid colon and has the highest incidence in the 40 to 50-year-old age group. Read More >
Research Trends
Rare Diseases Are Not Rare: The Mechanistic Research on Kennedy Disease (KD)
Sep 22, 2023
Kennedy disease (KD), also known as Spinal and Bulbar Muscular Atrophy (SBMA), is a recessive, X-linked, adult-onset motor neuron disease characterized by the slow, progressive weakness of the bulbar and limb muscles. Kennedy disease predominantly affects adult males, with an estimated global incidence of 1-2/100,000. Read More >
Research Trends
Do not give up chasing the light—Gene therapy aids the blind in regaining their sight
Sep 19, 2023
It is said that the eyes are the windows to the soul, but there are many people with congenital blindness who cannot "see" the light. According to publicly available data from the World Health Organization, there are at least 2.2 billion people globally with impaired vision or blindness. Read More >
Research Trends
Exploring the Power of the Cre-Lox System: Conditional Gene Targeting in Mice for In Vivo Applications
Sep 08, 2023
Conditional gene targeting in mice has revolutionized the field of molecular biology and genetic engineering. In vivo applications of the Cre-lox system are highly efficient, specific, and versatile. The Cre-lox system is a powerful tool to manipulate and study gene function in vivo, and it relies on the Cre recombinase enzyme to induce site-specific recombination between two LoxP sites. Read More >