Autoimmune & Inflammation CRO Services
Drive your immunology drug development forward with Cyagen's comprehensive CRO solutions for autoimmune and inflammatory diseases. Benefit from our proven models and expert support to expedite your path to therapeutic breakthroughs.
One-Stop Autoimmune & Inflammation CRO Solutions
Cyagen provides one-stop CRO solutions for autoimmune and inflammation drug discovery,
offering both genetically engineered and induced disease models alongside full-spectrum in vivo and in vitro
efficacy services. With extensive experience in modeling RA, SLE, IBD, and other disorders, our platform
supports both basic research and translational studies — delivering data-driven insights for IND submissions and
therapeutic innovation.
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Cyagen offers a wide selection of validated autoimmune and inflammatory disease
models, including both genetically engineered and chemically induced mouse models. These models
support translational research across diseases like rheumatoid arthritis, psoriasis, systemic lupus
erythematosus (SLE), inflammatory bowel disease (IBD), and more.
Base Strain
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We provide in vivo pharmacodynamic services tailored to autoimmune and inflammatory
disease research. Our robust model systems and optimized study protocols help assess treatment
efficacy under clinically relevant conditions.
Model Customization
Genetically engineered (e.g., Il10 KO, Tlr4 KO) and chemically induced
(e.g., IMQ-induced psoriasis, DSS-induced IBD) models available.
Disease-Specific Endpoints
Weight change, organ index, PASI scoring, proteinuria, anti-dsDNA levels,
and histopathological scoring.
Multimodal Validation Tools
- Histology: H&E, IHC, and IF
- Biochemical assays: ELISA, qPCR
- Immune profiling: Flow cytometry
- Imaging-based assessments
Need customized disease models or scoring endpoints for your study?
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Verify treatment efficacy and mechanism of action through detailed tissue-level
analysis and molecular assays. Cyagen provides end-to-end solutions for ocular histopathology,
molecular profiling, and biomarker validation—supporting your IND filings with reliable,
publication-ready data.
Immunoassays
- ELISA for cytokines and antibodies (e.g., anti-dsDNA, IgE)
- Multiplex cytokine profiling (Luminex/MSD/FACS)
Pathology & Imaging
- H&E, IHC, and IF analysis for inflamed tissues (skin, kidney, lung, joints)
Molecular Tools
- RNA extraction, qPCR, WB for target validation
Flow Cytometry
- For T/B/NK cell profiling, Th1/Th2/Th17 balance, activation markers
Need help with histopathology or cytokine biomarker analysis?
Case Examples
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Our Unique Advantages
Broad Model Coverage for Immune-Related Disorders
Our platform offers an extensive collection of genetically engineered and chemically induced models covering IBD, SLE, RA, AD, and more—empowering precise evaluation across various autoimmune and inflammatory diseases.
End-to-End In Vivo & In Vitro Testing
From disease modeling and treatment administration to tissue analysis and biomarker validation, we deliver complete preclinical workflows that meet IND-enabling study requirements.
Data-Driven Insights with Publication-Grade Rigor
Each project benefits from expert-designed protocols, standardized readouts (e.g., histopathology, flow cytometry, qPCR), and reproducible data—accelerating the path from discovery to clinical translation.
Request a Preclinical CRO Services Consultation
Partner with Cyagen to advance your preclinical studies. Share your project goals with us and receive customized support.
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