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Humanized Target Gene Disease Models
Transform uncertainty into genetically precise solutions. Engineer humanized targets for CAR-T, PD-1, or hematologic studies with TurboKnockout® technology—accelerating your path to actionable insights.

Clinically Validated Systems
Streamline testing of oncology, immunotherapies, and hematologic drugs in pre-validated, humanized environments.
Accelerated Model Development
Achieve 50% faster model delivery through gene-based engineering, outpacing traditional methods.
Custom Human Gene Integration
Seamlessly replace animal genes with human sequences to replicate disease mechanisms with unmatched accuracy.
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FAQs
Overview
Accelerate Therapeutic Validation with Human-Relevant Precision
Leverage cutting-edge gene-engineered models powered by TurboKnockout® to validate CAR-T, PD-1, and hematologic therapies in systems that mirror human biology—translating results into clinically actionable insights.
Explore Ready-to-Use Mouse Models
Discover over 18,000 validated mouse strains—including knockout, conditional knockout, and humanized models—covering 20+ research areas such as oncology, neurology, and metabolism. All models are supported by detailed genotype data and guaranteed quality, helping you fast-track discovery with confidence.
You Might Also Be Interested In
MouseAtlas Model Library
Search and access curated genetically engineered mouse strains
Oncology CRO Platform
End-to-end preclinical oncology support from models to IND data
Cardiometabolic CRO Platform
IND-ready studies using genetic and induced disease models
Gene Therapy CRO Platform
AI-guided AAV design and full-spectrum preclinical validation
Autoimmune & Inflammation CRO Platform
Advancing autoimmune drug discovery with models and efficacy data.
Rodent Breeding
Scalable colony expansion with full genotyping support
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Model Selection Made Simple
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Base Strain
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Catalog NumberNameBase StrainResearch ApplicationAction
I001220B6-hPCSK9/Apoe KOC57BL/6CyaDevelopment, screening, and preclinical evaluation of PCSK9-targeted drugs；Research on metabolic diseases such as hyperlipidemia, stroke, coronary heart disease, familial hypercholesterolemia (FH), and other atherosclerotic cardiovascular diseases (ASCVD)
C001601B6-hGLP-1R/obC57BL/6NCya;C57BL/6JCyaInvestigation of the pathogenesis of obesity and type 2 diabetes；Development and screening of drugs for obesity and type 2 diabetes；Research on other metabolic diseases such as cardiovascular and myocardial diseases；Study of the neuroprotective effect in nervous system diseases
C001779B6-hFOLH1 (hPSMA) C57BL/6NCyaFOLH1-targeted drug screening, development, and evaluation；Research on the pathological mechanisms and therapeutic approaches of hyperhomocysteinemia；Research on the pathological mechanisms and therapeutic approaches of various solid tumors like prostate cancer
C001787B6-hLAG3C57BL/6JCyaLAG3-targeted drug screening, development, and evaluation；Research on the pathological mechanisms and therapeutic approaches of malignant tumors such as melanoma, colorectal cancer, and non-small cell lung carcinoma；Research on the pathological mechanisms and therapeutic approaches of chronic infections including HIV infection, hepatitis B, and tuberculosis；Research on the pathological mechanisms and therapeutic approaches of autoimmune diseases like rheumatoid arthritis and Hashimoto's thyroiditis
C001783B6-hFAPC57BL/6NCyaFAP-targeted drug screening, development, and evaluation；Research on the pathological mechanisms and therapeutic approaches of malignant tumors
C001588TG-hAPOC3C57BL/6NCyaDevelopment, screening, and preclinical efficacy evaluation of therapeutics targeting human APOC3；Investigation of the pathogenic mechanisms and therapeutic strategies for hypertriglyceridemia (HTG)
C001522B6-hLPA (CKI) /Alb-creC57BL/6NCyaResearch on atherosclerosis, hyperlipidemia, thrombotic cardiovascular diseases, etc.；Preclinical evaluation of human LPA-targeted drugs
C001809B6-hTSLPC57BL/6NCyaTSLP-targeted drug screening, development, and evaluation；Research on the pathological mechanisms and therapeutic approaches of allergic and inflammatory diseases
C001772B6-hIL13/hIL23AC57BL/6NCyaScreening and development of IL13/IL23A-targeted therapeutics, and preclinical pharmacodynamic and safety evaluations；Research on the pathological mechanisms and therapeutic strategies for allergic and inflammatory diseases, immune-related disorders, and cancer
C001800B6-hHAVCR2C57BL/6JCyaHAVCR2-targeted drug screening, development, and evaluation；Research on the pathological mechanisms and therapeutic approaches of various inflammatory diseases and cancers
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FAQs
Frequently Asked Questions (FAQs)
Can models combine multiple genes (e.g., CD47 + SIRPα)?
Multiplex Humanization: Models like B6-hCD47/hSIRPα demonstrate 4.7-fold increased tumor clearance with dual blockade.
Conditional Systems: Tissue-specific co-expression (e.g., Tet-On) ensures <2% leaky expression.
How does TurboKnockout-Pro® minimize mosaicism in sickle cell models?
High-Fidelity Editing: eSpCas9(1.1) reduces off-target effects by >95%.
ESC Cloning: Achieve >90% germline transmission and screen for variants via 30x WGS.
How is the mouse strain selected for rare neurological disorders?
Mechanism-Driven Choice: Prioritize strains like C57BL/6J-SOD1G93A for ALS.
Genetic Purity: Backcross humanized alleles into >98% pure backgrounds.
Phenotypic Screening: Pre-screen strains to identify clinically relevant modifiers.
How do you validate human protein expression levels (e.g., PD-L1)?
Transcriptomic: NanoString® analysis confirms mRNA within ±15% of human baselines.
Proteomic: Flow cytometry benchmarks PD-L1 density to clinical samples (2,000–5,000 molecules/cell).
Functional: Anti-PD-1 response correlation of R²=0.78 with clinical data.
Can you share CAR-T toxicity data from models like B6-hCD47?
Off-Target Effects: B6-hCD47 models showed <5% off-target lysis of CD47+ stromal cells (7-AAD/Annexin V assays).
CRS Correlation: Humanized IL6/IL6R models achieved 89% alignment between murine cytokine spikes and clinical CRS grading.
How do you ensure humanized gene functionality in complex diseases like leukemia?
Our multi-tiered validation strategy ensures functional fidelity:
Pathway Alignment: Retain murine regulatory elements (e.g., promoters) while replacing coding sequences with human counterparts, mitigating interspecies discrepancies in pathways like JAK-STAT.
Functional Testing: Validate via CAR-T efficacy assessments and PDX engraftment, as demonstrated in RIKEN’s ALL studies.
Receptor-Ligand Compatibility: Co-humanize interacting pairs (e.g., PD-1/PD-L1) to preserve binding affinity.
What Customers Say About Cyagen
Violet Shimmer
Stanford University
The service provided to us by Cyagen is now in press at Nature as an article.
Scarlett Rouge
Seattle Children’s Hospital
We are very pleased with the state-of-the-art professional transgenic services provided by Cyagen for our study published recently in Nature. We continue to use Cyagen’s transgenic services as it allows us to do better and more efficient research with transgenic mice.
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