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Animal Models
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Transgenic Rats
Transgenic Rats
Discover Cyagen's advanced transgenic rat services, utilizing cutting-edge methods for precise genetic modifications. Our established Regular and PiggyBac transgenesis techniques offer robust and dependable gene integration solutions, perfect for complex disease modeling and functional studies.
Knockin Cell Lines
Knockin Cell Lines
Drive your experiments using site-specific modifications that support gene regulation studies, disease modeling, and drug screening. Our knockin cell lines offer consistent insertion of reporters, point mutations, or fusion tags, delivering validated solutions for actionable insights in your next project.
HUGO-GTTM: Revolutionizing Humanized Mouse Models
HUGO-GT™ Humanized Mice
Accelerating Drug Discovery with Precise Genome-Wide Humanization
Experience accuracy and reliability in preclinical studies with HUGO-GT™ models, powered by our proprietary TurboKnockout-Pro technology.
BAC Transgenesis
BAC Transgenic
BAC (Bacterial Artificial Chromosome) transgenesis enables insertion of large genomic fragments—such as full genes with regulatory elements—into rodent genomes, ensuring faithful expression and supporting complex loci that are hard to replicate by other methods.
PiggyBac Transgenesis
PiggyBac Transgenesis
Cyagen’s PiggyBac transgenesis platform enables efficient generation of stable, single-copy transgenic rodent models with consistent gene expression. It offers a reliable and cost-effective alternative for studying gene function and overexpression in vivo.
Regular Transgenesis
Regular Transgenic
Regular transgenesis is a widely used method for generating rodent models with strong transgene expression. Through pronuclear injection, it enables in vivo studies of gene overexpression and regulatory elements.
ES Cell Gene Targeting
ES Cell Gene Targeting
Cyagen’s ES Cell Gene Targeting platform leverages homologous recombination in murine embryonic stem (ES) cells to deliver highly precise, complex gene modifications. It is ideal for conditional knockouts, reporter knockins, humanized models, and large-fragment insertions.
Cre Mouse Models for Gene Research
Cre Mouse Lines
Control gene expression in time and space. The Cre/loxP system lets you modify genes in specific tissues and at defined times, by utilizing the Cre/loxP recombination technique, you can create genetically modified mice that allow for targeted gene modification. Every experiment advances. Every modification matters.
Autoimmune Disease Models
Autoimmune Disease Models
Reduce technical risk with rigorously validated, publication-ready models (e.g., BSA+CCL4+LPS-induced IgA Nephropathy) and TurboKnockout®-engineered efficiency (60% faster gene editing). Ethically optimized designs align with 3R principles to streamline IND-enabling studies.
Humanized Immune System Mouse Models
Humanized Immune System Mouse Models
Cyagen’s huPBMC, huHSC, and huBLT models deliver >80% CD45+ engraftment with GLP-compliant protocols and 12-week rapid generation. Achieve translational accuracy in preclinical studies for oncology, autoimmune, and infectious disease research—minimize variability and meet IND milestones faster.
Animal Models
BALB/c-hIL13
HUGO-GT™ Platform
Humanized Target Gene Models
Specialized Disease Models
Immune Target Humanized Models
Cytokine Humanized Models
Full-Gene Humanized Models
Autoimmune Disease Models
The BALB/c-hIL13 mouse is a humanized model constructed using gene editing technology to replace the sequence of the mouse Il13 gene in situ with the corresponding sequence from the human IL13 gene. This model can be used for studying the pathological mechanisms and therapeutic approaches of allergic and inflammatory diseases, and for the development of IL13-targeted drugs.
C57BL/6JCya-Crnkl1em1flox/Cya
KO/cKO Mouse Models
Crnkl1 is located on chromosome 2 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Crnkl1 conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Pcyox1em1flox/Cya
KO/cKO Mouse Models
Pcyox1 is located on chromosome 6 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Pcyox1 conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Appbp2em1flox/Cya
KO/cKO Mouse Models
Appbp2 is located on chromosome 11 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Appbp2 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
C57BL/6JCya-Acadsbem1flox/Cya
KO/cKO Mouse Models
Acadsb is located on chromosome 7 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Acadsb conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
C57BL/6JCya-Lonp2em1flox/Cya
KO/cKO Mouse Models
Lonp2 is located on chromosome 8 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Lonp2 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
C57BL/6JCya-Stard9em1flox/Cya
KO/cKO Mouse Models
Stard9 is located on chromosome 2 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Stard9 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
C57BL/6JCya-Rnf128em1flox/Cya
KO/cKO Mouse Models
Rnf128 is located on chromosome X of mice. SgRNA and ssDNA were designed using Nuclease Technology; Rnf128 conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Lman2em1flox/Cya
KO/cKO Mouse Models
Lman2 is located on chromosome 13 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Lman2 conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
C57BL/6JCya-Eif4e3em1flox/Cya
KO/cKO Mouse Models
Eif4e3 is located on chromosome 6 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Eif4e3 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
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