Neuroscience CRO Services
Cyagen provides one-stop neuroscience CRO solutions from custom animal model generation to behavioral and molecular efficacy evaluation, enabling precise, rapid, and reliable preclinical research.
One-Stop Neuroscience CRO Solutions
Cyagen’s integrated neuroscience research platform provides specialized genetically engineered and induced animal models, precise drug delivery, and comprehensive behavioral, pathological, and molecular analyses. With over 2,000 validated neuroscience models and a proven track record supporting publications in top journals, we streamline your research from discovery to therapeutic validation—accelerating breakthroughs in Alzheimer’s, Parkinson’s, ALS, and other neurological disorders.
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Looking for a custom disease model not listed in our database?
Our scientific team can develop or adapt models to fit your study requirements.
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Cyagen provides precise, customizable in vivo drug administration services designed
specifically for neuroscience research. Our expert technical team ensures accurate and reproducible
drug delivery directly to targeted brain and spinal regions, verified through rigorous imaging and
protein expression analyses.
Administration Methods Include:
- Stereotactic brain injection
- Stereotactic brain injection
- Intracerebroventricular (ICV) injection
- Intravenous (tail vein) injection
- Additional routes: Intranasal, intramuscular, subcutaneous, intraperitoneal, and more
Need Customized Administration for Your Project?
Case Examples:
1. Precise Brain Region Targeting (Stereotactic Injection)
- Injected Substance: AAV9-CMV-EGFP-HGH
- Titer: 1.98×10¹⁴ vg/mL
- Dose: 1×10¹¹ vg/0.5μL per injection
- Injection Coordinates: -2mm, ±1.8mm, -1.5mm
- Validation: Clear GFP expression 4 weeks post-injection, demonstrating accuracy and successful delivery.
Figure 1. Imaging demonstrates accurate
stereotactic delivery and localized expression of target protein.
2. Precise Brain Region Targeting (Stereotactic Injection)
- Injected Substance: AAV9-CMV-EGFP-HGH / AAV9-CAG-EGFP
- Titer & Dose: 4×10¹¹ vg (CMV); 1×10¹¹ vg (CAG)
- Injection Site: Lumbar vertebrae L4-L5
- Injection Coordinates: -2mm, ±1.8mm, -1.5mm
- Validation: Robust protein expression observed at 2 weeks post-injection, confirming effective intrathecal drug delivery.
Figure 2. Clear GFP signal indicates successful intrathecal injection and
target protein expression.
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Cyagen’s neuroscience CRO platform provides comprehensive and reliable evaluations
covering behavioral assessments, pathology, molecular biology, and pharmacological analyses. Our
internationally standardized assays enable accurate and reproducible measurement of neurological
outcomes and therapeutic efficacy, supporting researchers worldwide from preclinical validation to
clinical translation.
Behavioral Assays
- Morris Water Maze
- Y Maze
- Rotarod
- Open Field Test (OFT)
- Novel Object Recognition Test (NORT)
- Elevated Plus Maze (EPM)
- Forced Swimming Test (FST)
- Grip Strength Test
- Social Interaction Tests
- Treadmill & Balance Beam Test
- Tail Suspension Test and more
Pathological Analysis
- Tissue preparation and sectioning
- H&E staining
- Immunohistochemistry (IHC)
- Immunofluorescence staining (IF)
- Special staining techniques
- Fluorescent imaging & biomarker detection
- Apoptosis and proliferation analysis
Biochemical Analysis
- Quantitative PCR (qPCR)
- RT-PCR, Southern blot
- Western blot & ELISA
- Protein expression and localization
- Biomarker profiling
- Cytokine and inflammatory marker analysis
- Primer design & RNA extraction
Need Tailored Phenotypic & Efficacy Evaluations for Your Study?
Our Unique Advantages
Extensive & Validated Model Library
Rapid access to over 2,000 validated neuroscience mouse models, including KO, cKO, and HUGO-GT™ humanized models—ready-to-use within 48 hours to jumpstart your research.
Precise Drug Delivery & Reliable Results
Our skilled specialists perform targeted in vivo drug administration to precise CNS regions, with rigorous validation to guarantee reproducible and accurate data.
Comprehensive & Customizable Analysis
International-standard neurobehavioral testing paired with molecular, biochemical, and pathological analyses—fully supported by senior neuroscience experts.
Request a Preclinical CRO Services Consultation
Partner with Cyagen to advance your preclinical studies. Share your project goals with us and receive customized support.
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