Ophthalmic CRO Services
Cyagen offers comprehensive ophthalmic CRO solutions, from custom animal models to drug administration and validation, ensuring efficient and reliable results throughout preclinical research.
One-Stop Ophthalmology CRO Solutions
At Cyagen, we leverage over 18 years of experience in gene therapy and advanced technical
infrastructure to deliver end-to-end ophthalmology research solutions. Our platform supports ocular drug
development with a wide range of customized disease models, advanced in vivo drug administration, and
comprehensive phenotyping and molecular validation. With a proven track record of delivering over 500 CRO
projects and accelerating more than 20 IND applications, we ensure precise, efficient, and reliable results at
every stage of your research.
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At Cyagen, we provide a solid foundation for your ophthalmic research with over 20 validated
humanized and genetic models targeting common ocular diseases such as glaucoma, macular
degeneration, and diabetic retinopathy. We also specialize in creating custom animal models,
including knockout, knockin, and humanized models, tailored to meet the specific needs of your
studies.
Base Strain
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At Cyagen, we offer advanced in vivo drug delivery and phenotyping services
tailored for ophthalmic studies. From precise ocular injections to high-resolution imaging and
vision behavior analysis, our platform provides comprehensive capabilities to evaluate drug efficacy
and safety. Supported by expert personnel and cutting-edge instrumentation, we ensure consistent,
accurate, and reproducible preclinical results.
Custom Injection Methods
- Intracameral injection
- Intravitreal injection
- Subretinal injection
- Subconjunctival injection
- Retrobulbar injection
- Ensures accurate localization and minimal variability, overall > 90% success rate
Non-Invasive Imaging
- Fundus photography (FP)
- Fundus autofluorescence (GFP/mCherry) imaging
- Fundus fluorescein angiography (FFA)
- Optical Coherence Tomography (OCT)
- Laser photocoagulation
- Slit lamp microscopy
- Indirect ophthalmoscopy
- Intraocular pressure (IOP)
- Flash electroretinogram (f-ERG)
- Flash visual evoked potentials (f-VEP)
- Corneal damage fluoroscopy
- Corneal Confocal Microscopy Examination
Vision Behavioral Testing
- Visual optomotor response (OMR) test
- Water-maze visual discrimination test
- Visual Light/Dark box discrimination test
- Visual Reflex Assessment
Need tailored injection methods or behavioral assays for your ocular
study?
Case Examples
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Verify treatment efficacy and mechanism of action through detailed tissue-level
analysis and molecular assays. Cyagen provides end-to-end solutions for ocular histopathology,
molecular profiling, and biomarker validation—supporting your IND filings with reliable,
publication-ready data.
Tissue Collection & Preparation
- Precise dissection of ocular tissues (Retina, RPE cell, cornea, iris, atrial fluid, lens, vitreous, optic nerve, choroid+ sclera)
- Specialized handling to preserve structure and biomarker integrity for PK/PD study
Histological Analysis
- Paraffin sections and frozen sections
- Retinal/RPE and choroidal flat-mounts
- H&E staining, immunohistochemistry (IHC), and immunofluorescence (IF)
- Morphological assessment and pathology scoring
Molecular Assays
- Western Blot for protein expression profiling
- qPCR/RT-PCR for gene expression analysis
- Droplet digital PCR (ddPCR) for ultrasensitive absolute quantification
- ELISA for cytokine and secreted protein quantification
- Flow cytometry for multiparametric cell analysis and sorting
- Biomarker discovery and mechanism validation
Need support for molecular and histological validation?
Case Examples
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Our Unique Advantages
Extensive Library of Validated Ocular Models
Cyagen offers a wide range of ready-to-use and customizable mouse models—including genetic, humanized, and induced types—covering major ocular diseases such as glaucoma, AMD, DR, and RP.
Full-Spectrum Efficacy Evaluation Platform
Our platform integrates precise ocular drug delivery, in vivo imaging (OCT/ERG/FFA), behavioral testing, and molecular pathology to deliver comprehensive efficacy evaluation.
Trusted CRO Partner for Translational Research
With 500+ projects completed and over 20 IND filings supported, Cyagen delivers reliable, publication-ready data that accelerates preclinical ophthalmic drug development.
Request a Preclinical CRO Services Consultation
Partner with Cyagen to advance your preclinical studies. Share your project goals with us and receive customized support.
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