hACE2-All CDS-B6J
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
hACE2-All CDS-B6J
Product ID
C001191
Gene Name
Background
C57BL/6JCya
Gene Alias
ACEH
Classification
Other Target Humanized Models,Autoimmune Disease Models,Infectious Disease Models
NCBI ID
Phenotype
Chromosome
X
Document
Note: When using this mouse strain in a publication, please cite “hACE2-All CDS-B6J mice (Catalog C001191) were purchased from Cyagen.”
Strain Description
This strain is a mouse Ace2 gene humanization model that uses gene editing technology to replace the endogenous mouse Ace2 gene sequence with human ACE2 CDS, preserving the mouse signal peptide sequence and achieving hACE2 expression directed by the endogenous mouse Ace2 regulatory element. This gene is located on the mouse chromosome X and homozygous females and heterozygous males are viable and fertile.
Application Area
COVID-19 and related diseases research
COVID-19 vaccine and antibody drug evaluation
Validation Data