Trp53 KO
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
Trp53 KO
Product ID
C001203
Gene Name
Background
C57BL/6JCya
Gene Alias
bbl; bfy; bhy; p44; p53; Tp53
Classification
--
NCBI ID
Phenotype
Chromosome
11
Document
Note: When using this mouse strain in a publication, please cite “Trp53 KO mice (Catalog C001203) were purchased from Cyagen.”
Strain Description
This strain is a mouse model lacking Trp53, which is a gene homologous to human TP53. Homozygous Trp53-KO male mice develop normally but are prone to spontaneous tumors. Homozygous Trp53-KO mice developed tumors, mainly lymphomas, and sarcomas, at three to six months of age, and heterozygous mice developed tumors at about 10 months of age. Homozygous males are viable and fertile, but homozygous females have reduced survival at weaning.
Application Area
Oncology research
Validation Data