Trem2 KO
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
Trem2 KO
Product ID
C001207
Gene Name
Background
C57BL/6NCya
Gene Alias
TREM-2; Trem2a; Trem2b; Trem2c
Classification
Metabolic Disease Models,Neurological Disease Models
NCBI ID
Phenotype
Chromosome
17
Document
Note: When using this mouse strain in a publication, please cite “Trem2 KO mice (Catalog C001207) were purchased from Cyagen.”
Strain Description
This strain is a mouse model with the Trem2 gene knocked out, which can be used to study the biological consequences of TREM2 functional loss. It can also be crossed with transgenic mice related to APP and tau proteins to study the impact of TREM2 functional loss in the context of amyloid degeneration and tau pathology. Homozygous Trem2 KO mice are viable and fertile.
Application Area
Research on the pathogenesis of neurodegenerative diseases
Studies on the impact of immune responses and inflammation on the nervous system
Screening and evaluation of potential drugs targeting Trem2 or its pathway
Research on the genetic mechanisms of diseases such as Nasu-Hakola disease
Studies on amyloid degeneration and tau protein pathology
Validation Data