K18-hACE2-2A-CreERT2
Product ID:
C001244
Background:
C57BL/6JCya
Documents:
Expressing Tissues/Cells:
Epithelia, including airway epithelia
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Model Name
K18-hACE2-2A-CreERT2
Product ID
C001244
Gene Name
Background
C57BL/6JCya
Gene Alias
ACEH
Classification
Other Target Humanized Models,Cre Driver Lines,Autoimmune Disease Models,Infectious Disease Models
NCBI ID
Phenotype
Chromosome
X
Document
Note: When using this mouse strain in a publication, please cite “K18-hACE2-2A-CreERT2 mice (Catalog C001244) were purchased from Cyagen.”
Strain Description
K18-hACE2 mice can be infected with the SARS-CoV-2 virus, resulting in severe disease characterized by weight loss, rapid respiration, hunched posture, and immobility. This strain responds to viral attack in a dose-dependent manner, thus allowing the study of severe acute respiratory disease in mice heavily infected by high doses of the virus, as well as the long-term effects of low doses of mild infection. The model should be handled in strict accordance with the guidelines for the prevention of SARS-CoV-2 virus infection in humans as specified by CDC&ABSA&WHO, and appropriate personal protective equipment (PPE) and handling methods should always be used when using these mice for research.
Application Area
COVID-19 and related diseases research
COVID-19 vaccine and antibody drug evaluation
Validation Data