ROSA26-LSL-hACE2
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Genotype
Sex
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Basic Information
Model Name
ROSA26-LSL-hACE2
Product ID
C001246
Gene Name
Background
C57BL/6JCya
Gene Alias
ACEH
Classification
Other Target Humanized Models,Autoimmune Disease Models,Infectious Disease Models
NCBI ID
Phenotype
Chromosome
X
Document
Note: When using this mouse strain in a publication, please cite “ROSA26-LSL-hACE2 mice (Catalog C001246) were purchased from Cyagen.”
Strain Description
This strain is a human ACE2 (hACE2) conditional overexpression model generated by integrating the hACE2 gene expression element into the mouse ROSA26 safe harbor site. Under normal conditions, the expression of hACE2 is blocked by the upstream loxP-Stop-loxP expression stop cassette. Upon mating with Cre mice, the Cre recombinase mediates the deletion of the sequence between the loxP sites, including the stop cassette, thereby enabling the expression of hACE2. When bred with tissue-specific Cre mice, overexpression of the hACE2 gene and protein can be achieved in specific tissues of the offspring mice. Homozygous ROSA26-LSL-hACE2 mice are viable and fertile.
Application Area
Cardiovascular function research
SARS-CoV-2 infection mechanism research
SARS-CoV-2 vaccine development evaluation
SARS-CoV-2 prevention and treatment drug screening evaluation
SARS-CoV-2 antibody drug development validation
Validation Data