Foxj1 KO
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
Foxj1 KO
Product ID
C001265
Gene Name
Background
C57BL/6NCya
Gene Alias
Hfh4; HFH-4; FKHL-13
Classification
Metabolic Disease Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
11
Document
Note: When using this mouse strain in a publication, please cite “Foxj1 KO mice (Catalog C001265) were purchased from Cyagen.”
Strain Description
Foxj1 (forkhead-box J1), also known as hepatocyte nuclear factor-3 (HNF-3) or forkhead homologue-4 (HFH-4), is a member of the forkhead-box transcription factor family, a class of transcription factors with a winged helix structure that binds to DNA. The Foxj1 factor plays a major regulatory role in controlling the transcription process of motile cilia synthesis. Airway cilia quickly clear airway mucus by swinging, playing a role in resisting pathogen invasion. It also has an effect on the left-right axis asymmetry of organ development during the embryonic period. Studies have shown that Foxj1 KO mice exhibit left-right asymmetric development and airway ciliated epithelium is lost in adult mice. The heterozygous Foxj1 KO mice are viable, while the homozygous mice are lethal.
Application Area
Research on Kartagener syndrome
Research on primary ciliary dyskinesia
Validation Data