Atp7b KO
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
Atp7b KO
Product ID
C001267
Gene Name
Background
C57BL/6NCya
Gene Alias
tx; WND; Atp7a
Classification
Metabolic Disease Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
8
Document
Note: When using this mouse strain in a publication, please cite “Atp7b KO mice (Catalog C001267) were purchased from Cyagen.”
Strain Description
This strain is an Atp7b deletion mouse model, which uses gene editing technology to knock out Atp7b, the homolog of the human ATP7B gene in mice that lack the expression of ATP7B protein and can be used in the study of disorders related to copper metabolisms such as Wilson's disease, acute liver failure, and steatohepatitis. The heterozygous Atp7b KO mice are viable and fertile, and homozygous mice have a reduced life expectancy.
Application Area
Copper Metabolism Research
Wilson’s Disease Research
Acute Liver Failure Research
Steatohepatitis Research
Other Research Related to Copper Metabolism Disorders
Validation Data