This strain contains a loxP-hACE2 CDS-loxP gene expression cassette inserted at the endogenous mouse Ace2 gene locus, which enables the regulation of human ACE2 gene (hACE2) expression by the mouse endogenous Ace2 regulatory element. When bred with relevant tissue-specific Cre mouse mating, knockout of the hACE2 gene can be achieved in specific tissues of the offspring mice. Homozygous LoxP-hACE2-CDStm mice are viable and fertile.