loxP-hACE2-CDStm
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Genotype
Sex
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Basic Information
Model Name
loxP-hACE2-CDStm
Product ID
C001281
Gene Name
Background
C57BL/6NCya
Gene Alias
ACEH
Classification
Other Target Humanized Models,Autoimmune Disease Models,Infectious Disease Models
NCBI ID
Phenotype
Chromosome
X
Document
Note: When using this mouse strain in a publication, please cite “loxP-hACE2-CDStm mice (Catalog C001281) were purchased from Cyagen.”
Strain Description
This strain contains a loxP-hACE2 CDS-loxP gene expression cassette inserted at the endogenous mouse Ace2 gene locus, which enables the regulation of human ACE2 gene (hACE2) expression by the mouse endogenous Ace2 regulatory element. When bred with relevant tissue-specific Cre mouse mating, knockout of the hACE2 gene can be achieved in specific tissues of the offspring mice. Homozygous LoxP-hACE2-CDStm mice are viable and fertile.
Application Area
Cardiovascular function research
SARS-CoV-2 infection mechanism research
SARS-CoV-2 vaccine development evaluation
SARS-CoV-2 prevention and treatment drug screening evaluation
SARS-CoV-2 antibody drug development validation
Validation Data