Lep KO (ob/ob)
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
Lep KO (ob/ob)
Product ID
C001368
Gene Name
Background
C57BL/6JCya
Gene Alias
ob; obese
Classification
Metabolic Disease Models
NCBI ID
Phenotype
Chromosome
6
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Note: When using this mouse strain in a publication, please cite “Lep KO (ob/ob) mice (Catalog C001368) were purchased from Cyagen.”
Strain Description
This strain is a Lep deletion mouse model that uses gene editing technology to knock out the expression of human LEP gene homolog in mice with impaired leptin synthesis. According to the literature, this mouse model exhibits obesity, excessive food intake, transient hyperglycemia, poor glucose tolerance, and elevated plasma insulin, accompanied by hypometabolism, hypothermia, and low fertility, in addition to impaired wound healing and increased production of hormones by their pituitary and adrenal glands; The phenotype is more similar to that of type II diabetes and obesity in stages I and II, with an increase in the number and size are increased, which can be used in obesity and type II diabetes studies. Homozygous Lep KO mice are viable but the females are sterile and the males have reduced fecundity.
Application Area
The Lep KO mice can be used for the study of type II diabetes, obesity diseases, endocrine defects, and other metabolic diseases
Validation Data