Prph2 KO
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
Prph2 KO
Product ID
C001385
Gene Name
Background
C57BL/6JCya
Gene Alias
RP7; Rd2; Rds; rds; AVMD; PRPH; Rd-2; AOFMD; Nmf193; Tspan22
Classification
Ophthalmic Disease Models
NCBI ID
Phenotype
Chromosome
17
Document
Note: When using this mouse strain in a publication, please cite “Prph2 KO mice (Catalog C001385) were purchased from Cyagen.”
Strain Description
This strain is a mouse Prph2 knockout model that uses gene editing technology to knock out the homolog of the human PRPH2 gene in mice. The deletion of Prph2 gene expression in mice leads to abnormalities in the morphogenesis of the outer segmental disc and the conduction of light signals, causing more delayed retinal degeneration (RD), and the progression of ocular retinal disease in this model is similar to that of mice carrying the RD2 spontaneous mutation in the mouse Prph2 gene, which is a class of animal models of delayed retinal degeneration.
Application Area
Retinitis Pigmentosa (RP) Research
Age-related Macular Degeneration (AMD) Research
Macular Dystrophy (MDs) Research
Validation Data