hVEGFA-TG
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Genotype
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Basic Information
Model Name
hVEGFA-TG
Product ID
C001395
Gene Name
Background
C57BL/6JCya
Gene Alias
VPF; VEGF; MVCD1; L-VEGF
Classification
Other Target Humanized Models,Ophthalmic Disease Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
6
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Note: When using this mouse strain in a publication, please cite “hVEGFA-TG mice (Catalog C001395) were purchased from Cyagen.”
Strain Description
The hVEGFA-TG mouse is a transgenic model generated by Cyagen. In this model, the expression of human VEGFA CDS is driven by the bovine rhodopsin promoter, allowing for specific overexpression of the human VEGFA gene in the retina without affecting the expression of the endogenous VEGFA gene. This model exhibits clear retinal and choroidal vascular lesions while maintaining complete eye structure and can naturally develop diseases. Anti-VEGF drugs such as Aflibercept have been evaluated for efficacy in this mouse model, demonstrating that Aflibercept can target and suppress VEGF expression, thereby alleviating retinal vascular lesions. As such, this model is well-suited for drug evaluation and mechanism research related to neovascular ophthalmic diseases.
Application Area
Research on Age-Related Macular Degeneration (AMD)
Research on Diabetic Retinopathy (DR)
Research on corneal neovascular diseases
Validation Data