B6J-hANGPTL3
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
B6J-hANGPTL3
Product ID
C001400
Gene Name
Background
C57BL/6JCya
Gene Alias
ANL3; ANG-5; FHBL2; ANGPT5
Classification
Metabolic Target Humanized Models,Cytokine Humanized Models,Full-Gene Humanized Models,Metabolic Disease Models
NCBI ID
Phenotype
Chromosome
1
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Note: When using this mouse strain in a publication, please cite “B6J-hANGPTL3 mice (Catalog C001400) were purchased from Cyagen.”
Strain Description
This strain is a mouse Angptl3 gene humanized model. The mouse Angptl3 gene is replaced with the human ANGPTL3 gene sequence by gene editing technology, which expresses the human ANGPTL3 protein while retaining the signal peptide of mouse Angptl3. This model can be used to study the pathogenesis of metabolic diseases such as atherosclerosis, diabetes, and familial combined hyperlipidemia (FCH), as well as the development and screening of ANGPTL3-targeted drugs. The homozygous B6J-hANGPTL3 mice are viable and fertile.
Application Area
Metabolic diseases such as atherosclerosis and hyperlipidemia
Angiogenesis and endothelial cell adhesion
Development and screening of ANGPTL3-targeted drugs
Validation Data