FVB-HTT KI (nQ)
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
FVB-HTT KI (nQ)
Product ID
C001404
Gene Name
Background
FVB/NJCya
Gene Alias
HD; IT15; LOMARS
Classification
Other Target Humanized Models,Neurological Disease Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
4
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Note: When using this mouse strain in a publication, please cite “FVB-HTT KI (nQ) mice (Catalog C001404) were purchased from Cyagen.”
Strain Description
This strain is an hHTT gene knock-in mouse model generated by gene editing technology, in which a mutated human HTT gene sequence carrying over 100 CAG repeats is inserted into the mouse genome. Mice carrying these mutations have been reported to exhibit pathological characteristics and functional impairment phenotypes of Huntington’s disease and can be used for the development and screening of therapeutic drugs for Huntington's disease as well as for safety evaluation. The detection data shows that this model can successfully express the mutated human HTT gene and protein.
Application Area
Development and screening of therapeutic drugs for Huntington's disease
Evaluation of therapeutic drug efficacy and safety for Huntington's disease
Research on the pathogenesis of Huntington's disease
Validation Data