LSL-K-ras G12C
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Basic Information
Model Name
LSL-K-ras G12C
Product ID
C001409
Gene Name
Background
C57BL/6JCya
Gene Alias
ras; p21B; K-Ras; K-ras; Kras2; Ki-ras; Kras-2; K-Ras 2; c-K-ras; c-Ki-ras
Classification
Oncology & Immuno-oncology Models
NCBI ID
Phenotype
Chromosome
6
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Note: When using this mouse strain in a publication, please cite “LSL-K-ras G12C mice (Catalog C001409) were purchased from Cyagen.”
Strain Description
This strain is a conditional expression model of K-ras G12C, generated by introducing the G12C point mutation into the mouse Kras gene. Under normal conditions, the expression of K-ras G12C is blocked by an upstream loxP-Stop-loxP cassette. Expression is achieved only upon crossing with Cre mice, where Cre recombinase-mediated loxP site recombination removes the blocking sequence. This enables precise temporal and spatial control of K-ras G12C expression and tumorigenesis. By mating with tissue-specific Cre mice, this model can conditionally express K-ras G12C in specific tissues, making it a valuable tool for constructing cancer models in various tissues and organs. Homozygous LSL-K-ras G12C mice are nonviable.
Application Area
This strain can be crossed with tissue-specific Cre mice to construct tumor models for various tissues or organs. It is suitable for applications such as drug screening and pharmacodynamic evaluations
Validation Data