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FVB-Abcb1a & Abcb1b DKO (Mdr1a/b KO)
Product ID:
C001493
Background:
FVB/NJCya
Documents:
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Basic Information
Model Name
FVB-Abcb1a & Abcb1b DKO (Mdr1a/b KO)
Product ID
C001493
Gene Name
Abcb1a, Abcb1b
Background
FVB/NJCya
Gene Alias
Pgp; Mdr3; P-gp; Pgy3; Abcb4; Evi32; Mdr1a; Pgy-3; mdr-3; mdr; Mdr1; Pgy1; Abcb1; Mdr1b; Pgy-1
Classification
Neurological Disease Models,Other Disease Models
NCBI ID
18671, 18669
Phenotype
MGI:97570, MGI:97568
Chromosome
5
More
Rare Disease Data Center >>
Document
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Note
Note: When using this mouse strain in a publication, please cite “FVB-Abcb1a & Abcb1b DKO (Mdr1a/b KO) mice (Catalog C001493) were purchased from Cyagen.”
Strain Description
This strain is an MDR1 knockout model, in which the human ABCB1 gene's homologous genes, Abcb1a and Abcb1b, were knocked out in mice using gene editing technology. This model lacks the expression of MDR1 protein and can be used for research in areas such as blood-brain barrier permeability-related diseases and multidrug resistance of anti-tumor drugs.
Application Area
Area
Research on blood-brain barrier permeability-related diseases
Area
Research on multidrug resistance of anti-tumor drugs
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