FVB-Abcb1a & Abcb1b DKO (Mdr1a/b KO)
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Basic Information
Model Name
FVB-Abcb1a & Abcb1b DKO (Mdr1a/b KO)
Product ID
C001493
Background
FVB/NJCya
Gene Alias
Pgp; Mdr3; P-gp; Pgy3; Abcb4; Evi32; Mdr1a; Pgy-3; mdr-3; mdr; Mdr1; Pgy1; Abcb1; Mdr1b; Pgy-1
Classification
Neurological Disease Models,Other Disease Models
Chromosome
5
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Note: When using this mouse strain in a publication, please cite “FVB-Abcb1a & Abcb1b DKO (Mdr1a/b KO) mice (Catalog C001493) were purchased from Cyagen.”
Strain Description
This strain is an MDR1 knockout model, in which the human ABCB1 gene's homologous genes, Abcb1a and Abcb1b, were knocked out in mice using gene editing technology. This model lacks the expression of MDR1 protein and can be used for research in areas such as blood-brain barrier permeability-related diseases and multidrug resistance of anti-tumor drugs.
Application Area
Research on blood-brain barrier permeability-related diseases
Research on multidrug resistance of anti-tumor drugs
Validation Data