B6-hCALCRL
Product Type
Age
Genotype
Sex
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Basic Information
Model Name
B6-hCALCRL
Product ID
C001497
Gene Name
Background
C57BL/6JCya
Gene Alias
CRLR; CGRPR; LMPHM8
Classification
Other Target Humanized Models,Neurological Disease Models
NCBI ID
Phenotype
Chromosome
2
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Note: When using this mouse strain in a publication, please cite “B6-hCALCRL mice (Catalog C001497) were purchased from Cyagen.”
Strain Description
This strain represents a humanized mouse model of the Calcrl gene. Using gene editing technology, the sequence encoding the extracellular domain of the mouse Calcrl gene was replaced with the corresponding sequence from the human CALCRL gene. This model can be used to study the mechanisms of various physiological and pathological processes, such as blood pressure regulation, cell proliferation, cell death, vascular biology, physiological bone marrow generation, inflammation, and tumor growth, as well as the development of CALCRL-targeted migraine drugs and therapies. Homozygous B6-hCALCRL mice are viable and fertile.
Application Area
Drug discovery and screening for migraine treatment
Efficacy and safety evaluation of migraine treatment drugs
Vascular biology and blood pressure regulation research
Cell proliferation and apoptosis research
Tumor growth inhibition and inflammation research
Hematopoietic stem/progenitor cell generation and differentiation research
Validation Data