KS (inducible)
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Genotype
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Basic Information
Model Name
KS (inducible)
Product ID
C001514
Gene Name
Background
C57BL/6JCya
Gene Alias
ras; p21B; K-Ras; K-ras; Kras2; Ki-ras; Kras-2; K-Ras 2; c-K-ras; c-Ki-ras
Classification
Oncology & Immuno-oncology Models
NCBI ID
Phenotype
Chromosome
6
Document
Note: When using this mouse strain in a publication, please cite “KS (inducible) mice (Catalog C001514) were purchased from Cyagen.”
Strain Description
The KS (inducible) mouse is an induced lung cancer model that is constructed by crossing LSL-K-ras G12D mice (Catalog number: C001064), a conditional over-expressing K-Ras G12D mutant gene mouse strain, and Sftpc-MerCreMer mice (Catalog number: C001501), a type II alveolar cell-specific Cre recombinase expressing mouse strain, and then inducing with tamoxifen. Tamoxifen can trigger sequence recombination between loxP sites mediated by Cre recombinase in the type II alveolar cells of the offspring mice, resulting in the specific deletion of the Loxp-Stop-Loxp (LSL) gene silencing element in the type II alveolar cells, thereby enabling the K-Ras G12D mutant gene to be selectively expressed in the lung tissue. Internal data indicates that the model may exhibit slight expression leakage in the absence of tamoxifen induction, leading to the occurrence of a small number of pulmonary adenomas.
Application Area
KS (inducible) mice can be used to study the mechanisms of the occurrence and metastasis of non-small cell lung cancer (NSCLC), as well as the screening, development, and evaluation of therapeutic drugs.
Validation Data