huHSC-NKG-hIL15
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Genotype
Sex
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Basic Information
Model Name
huHSC-NKG-hIL15
Product ID
C001526
Background
NKG
Gene Alias
gc; p64; [g]c; CD132; gamma(c); IL-15
Classification
Immunodeficient Mouse Models,Humanized Immune System Models
Phenotype
Chromosome
X
Document
Note: When using this mouse strain in a publication, please cite “huHSC-NKG-hIL15 mice (Catalog C001526) were purchased from Cyagen.”
Strain Description
The huHSC-NKG-hIL15 mouse refers to an immune system humanized mouse model constructed by transplanting human hematopoietic stem cells (HSC) into NKG-hIL15 mice after sub-lethal dose irradiation. This model can reconstitute various immune cells, has a long lifespan, and is particularly effective in rebuilding human NK cells, which can aid in the development of NK cell-related tumor immunotherapies.
Application Area
Research on the human immune system, haematopoietic system
Human-derived cell line xenograft (CDX) and patient-derived xenograft (PDX)
NK cell development mechanism studies, NK cell-related tumor immunotherapy development, and antibody-dependent NK cell-mediated toxicity (ADCC) studies
Validation Data
References
Research
Jan, 2025
Essential Regulation of Spermatogonial Stem Cell Fate Decisions and Male Fertility by APBB1 via Interaction with KAT5 and GDF15 in Humans and Mice
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