B6-RCL-hLPA/Alb-cre/TG (APOB)
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Sex
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Basic Information
Model Name
B6-RCL-hLPA/Alb-cre/TG (APOB)
Product ID
C001553
Background
C57BL/6Cya
Gene Alias
LP; AK38; APOA; FLDB; FCHL2; LDLCQ4; apoB-48; apoB-100
Classification
Cytokine Humanized Models,Metabolic Disease Models
Phenotype
Chromosome
6
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Note: When using this mouse strain in a publication, please cite “B6-RCL-hLPA/Alb-cre/TG (APOB) mice (Catalog C001553) were purchased from Cyagen.”
Strain Description
The B6-RCL-hLPA/Alb-cre/TG (APOB) mice express human LP(a) and ApoB, two risk factors for cardiovascular disease. It can be used in the study of hyperlipidemia, stroke, coronary heart disease, familial hypercholesterolemia (FH), and other atherosclerotic cardiovascular diseases (ASCVD). Internal data (not shown) indicates that, compared to the Cyagen strain B6-LPA (CKI) /Alb-Cre & Tg (APOB) mice (Catalog No. C001494), this model exhibits a more stable expression of human LPA protein at different ages. Please choose the model based on the experimental need for continuous stability of human LPA protein expression.
Application Area
Development and evaluation of LP(a) and ApoB targeted drugs
Research on familial hypercholesterolemia (FH)
Research on atherosclerotic cardiovascular disease (ASCVD)
Research on other cardiovascular diseases (CVD)
Validation Data