Jak2*V617F
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
Jak2*V617F
Product ID
C001564
Gene Name
Background
C57BL/6JCya
Gene Alias
Fd17
Classification
Oncology & Immuno-oncology Models
NCBI ID
Phenotype
Chromosome
19
Document
Note: When using this mouse strain in a publication, please cite “Jak2*V617F mice (Catalog C001564) were purchased from Cyagen.”
Strain Description
The Jak2*V617F mice are generated by introducing a homologous mutation to the human JAK2 V617F into the mouse Jak2 gene via gene editing. This strain is homozygous lethal. Heterozygous Jak2*V617F mice exhibit classic MPN-like disease phenotypes such as splenomegaly and structural damage, significantly elevated red blood cell count, hemoglobin, hematocrit, white blood cell count, platelet count, marked megakaryocytic hyperplasia (with granulocytic and erythroid hyperplasia), extramedullary hematopoiesis, and congestion of splenic sinusoids. Therefore, Jak2*V617F mice can be used for studying the mechanisms of myeloproliferative neoplasms (MPNs) like polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), as well as for evaluating therapeutic drugs.
Application Area
Research on JAK/STAT signaling pathway transduction
Research on Polycythemia Vera (PV), Essential Thrombocythemia (ET), and Primary Myelofibrosis (PMF)
Development and evaluation of therapeutic drugs for myeloproliferative neoplasms (MPNs)
Validation Data