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TG-hAPOC3
Product ID:
C001588
Background:
C57BL/6NCya
Documents:
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Basic Information
Model Name
TG-hAPOC3
Product ID
C001588
Gene Name
APOC3
Background
C57BL/6NCya
Gene Alias
Apo-C3; ApoC-3; APOCIII
Classification
Other Target Humanized Models,Metabolic Target Humanized Models,Metabolic Disease Models
NCBI ID
345
Phenotype
MGI:88055
Chromosome
11
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Rare Disease Data Center >>
Document
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Note
Note: When using this mouse strain in a publication, please cite “TG-hAPOC3 mice (Catalog C001588) were purchased from Cyagen.”
Strain Description
The TG-hAPOC3 mouse is a humanized model generated by integrating the human APOC3 gene sequence, encompassing the upstream and downstream untranslated regions (UTRs), into the mouse genome, enabling the expression of human ApoC-III protein in vivo. This model is valuable for developing therapeutics targeting human APOC3, such as small interfering RNA (siRNA) and antisense oligonucleotides (ASOs), for the treatment of hypertriglyceridemia.
Application Area
Area
Development, screening, and preclinical efficacy evaluation of therapeutics targeting human APOC3
Area
Investigation of the pathogenic mechanisms and therapeutic strategies for hypertriglyceridemia (HTG)
Validation Data
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