B6-h4-1BB (TNFRSF9)
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
B6-h4-1BB (TNFRSF9)
Product ID
C001604
Gene Name
Background
C57BL/6NCya
Gene Alias
ILA; 4-1BB; CD137; CDw137; IMD109
Classification
Tumor Target Humanized Models,Immune Target Humanized Models,Autoimmune Disease Models
NCBI ID
Phenotype
Chromosome
1
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Note: When using this mouse strain in a publication, please cite “B6-h4-1BB (TNFRSF9) mice (Catalog C001604) were purchased from Cyagen.”
Strain Description
The B6-h4-1BB (TNFRSF9) mouse is a humanized model. The sequence encoding the endogenous extracellular domain of the mouse Tnfrsf9 is replaced in situ with the sequence encoding the human TNFRSF9 extracellular domain. This model can be used for studies on cancer immunology and autoimmune diseases, as well as for the development, screening, and evaluation of 4-1BB agonists in preclinical research.
Application Area
Research on cancer immunotherapy and autoimmune diseases
Preclinical studies on the development, screening, and evaluation of 4-1BB agonists
Validation Data