B6-hATP7B*H1069Q
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Model Name
B6-hATP7B*H1069Q
Product ID
C001610
Gene Name
Background
C57BL/6NCya
Gene Alias
WD; PWD; WC1; WND
Classification
Full-Gene Humanized Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
13
Document
Note: When using this mouse strain in a publication, please cite “B6-hATP7B*H1069Q mice (Catalog C001610) were purchased from Cyagen.”
Strain Description
This strain is a humanized point mutation model constructed by introducing the common pathogenic mutation p.H1069Q (CAC>CAA) into the humanized ATP7B gene of B6-hATP7B mice (Catalog No.: I001130). This model is suitable for studying the pathogenic mechanisms of Wilson's disease, and homozygous animals are viable and fertile.
Application Area
Research on hepatolenticular degeneration (HLD)
Preclinical evaluation of ATP7B-targeted drugs
Validation Data