Ube3a KO
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Model Name
Ube3a KO
Product ID
C001611
Gene Name
Background
C57BL/6NCya
Gene Alias
Hpve6a; 4732496B02; 5830462N02Rik; A130086L21Rik
Classification
Neurological Disease Models,Rare Disease Models
NCBI ID
Phenotype
Chromosome
7
Document
Note: When using this mouse strain in a publication, please cite “Ube3a KO mice (Catalog C001611) were purchased from Cyagen.”
Strain Description
The Ube3a KO mouse is a gene knockout (KO) model, generated using gene editing technology to knock out the protein-coding sequence of the Ube3a gene (the homologous gene of human UBE3A gene) in mice. Preliminary behavioral data indicate that this model exhibits anxiety-like/compulsive behaviors, abnormal stress responses, and is accompanied by decreased spontaneous activity, shortened movement distance, and reduced average motility, among other motor function and behavioral abnormalities. It can be used for research on the pathogenesis of Angelman Syndrome (AS) and the development of related therapies.
Application Area
Research on the pathogenic mechanisms and therapeutic drugs of Angelman Syndrome (AS)
Other neurological system studies
Validation Data