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B6-hANG2 (ANGPT2)
Product ID:
C001615
Background:
C57BL/6JCya
Documents:
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Basic Information
Model Name
B6-hANG2 (ANGPT2)
Product ID
C001615
Gene Name
ANGPT2
Background
C57BL/6JCya
Gene Alias
ANG2; AGPT2; LMPHM10
Classification
Tumor Target Humanized Models,Cytokine Humanized Models,Full-Gene Humanized Models,Ophthalmic Disease Models
NCBI ID
285
Phenotype
MGI:1202890
Chromosome
8
More
Rare Disease Data Center >>
Document
Click here to download >>
Note
Note: When using this mouse strain in a publication, please cite “B6-hANG2 (ANGPT2) mice (Catalog C001615) were purchased from Cyagen.”
Strain Description
B6-hANG2 (ANGPT2) mouse model was generated using gene editing technology to replace the entire sequence of the mouse Angpt2 gene with the human ANGPT2 gene sequence, achieving stable expression of human ANGPT2 protein. This model is suitable for studying tumorigenesis, vascular hyperproliferative diseases (e.g., diabetic retinopathy, age-related macular degeneration), autoimmune disorders, and preclinical evaluation of human ANGPT2-targeted therapeutics.
Application Area
Area
Mechanistic studies of tumorigenesis and cancer progression
Area
Pathogenesis of vascular diseases and autoimmune disorders
Area
Development, screening, and preclinical pharmacodynamic evaluation of human ANGPT2-targeted therapeutics
Validation Data
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